Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation

J. A. Palanivel; A. E. Macbeth; N. J. Levell

doi:10.1111/j.1365-2230.2012.04375.x

Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation

J. A. Palanivel, A. E. Macbeth, N. J. Levell

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.

Original language	English
Pages (from-to)	44-46
Number of pages	3
Journal	Clinical and Experimental Dermatology
Volume	38
Issue number	1
Early online date	21 May 2012
DOIs	https://doi.org/10.1111/j.1365-2230.2012.04375.x
Publication status	Published - Jan 2013

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10.1111/j.1365-2230.2012.04375.x

Cite this

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title = "Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation",

abstract = "Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.",

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AB - Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.

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