Quantification of rheumatoid synovitis by magnetic resonance imaging

Karl Gaffney; John Cookson; David Blake; Adam Coumbe; Selina Blades

doi:10.1002/art.1780381113

Quantification of rheumatoid synovitis by magnetic resonance imaging

Karl Gaffney, John Cookson, David Blake, Adam Coumbe, Selina Blades

Research output: Contribution to journal › Article › peer-review

148 Citations (Scopus)

Abstract

OBJECTIVE: To develop a method for quantifying acute synovial inflammation in rheumatoid arthritis (RA), utilizing magnetic resonance imaging (MRI).

METHODS: Gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI was performed in 21 patients with knee synovitis. Changes in synovial membrane signal intensity were identified and quantified by line profile analysis. Multiple synovial biopsies were obtained by a blind biopsy technique, and standard clinical and laboratory measurements of disease activity were recorded.

RESULTS: The rate of synovial membrane enhancement correlated with histologic features of acute inflammation (r = 0.63, P < 0.01), but not with clinical or laboratory assessments.

CONCLUSION: Dynamic MRI is a valuable technique for assessing acute synovial inflammation in RA.

Original language	English
Pages (from-to)	1610-1617
Number of pages	8
Journal	Arthritis and Rheumatism
Volume	38
Issue number	11
DOIs	https://doi.org/10.1002/art.1780381113
Publication status	Published - Nov 1995
Externally published	Yes

Keywords

Adult
Aged
Arthritis, Rheumatoid/complications
Contrast Media
Female
Gadolinium DTPA
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organometallic Compounds
Pentetic Acid/analogs & derivatives
Synovitis/complications

Access to Document

10.1002/art.1780381113

Cite this

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title = "Quantification of rheumatoid synovitis by magnetic resonance imaging",

abstract = "OBJECTIVE: To develop a method for quantifying acute synovial inflammation in rheumatoid arthritis (RA), utilizing magnetic resonance imaging (MRI).METHODS: Gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI was performed in 21 patients with knee synovitis. Changes in synovial membrane signal intensity were identified and quantified by line profile analysis. Multiple synovial biopsies were obtained by a blind biopsy technique, and standard clinical and laboratory measurements of disease activity were recorded.RESULTS: The rate of synovial membrane enhancement correlated with histologic features of acute inflammation (r = 0.63, P < 0.01), but not with clinical or laboratory assessments.CONCLUSION: Dynamic MRI is a valuable technique for assessing acute synovial inflammation in RA.",

keywords = "Adult, Aged, Arthritis, Rheumatoid/complications, Contrast Media, Female, Gadolinium DTPA, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organometallic Compounds, Pentetic Acid/analogs & derivatives, Synovitis/complications",

author = "Karl Gaffney and John Cookson and David Blake and Adam Coumbe and Selina Blades",

year = "1995",

month = nov,

doi = "10.1002/art.1780381113",

language = "English",

volume = "38",

pages = "1610--1617",

journal = "Arthritis and Rheumatism",

issn = "0004-3591",

publisher = "Wiley",

number = "11",

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TY - JOUR

T1 - Quantification of rheumatoid synovitis by magnetic resonance imaging

AU - Gaffney, Karl

AU - Cookson, John

AU - Blake, David

AU - Coumbe, Adam

AU - Blades, Selina

PY - 1995/11

Y1 - 1995/11

N2 - OBJECTIVE: To develop a method for quantifying acute synovial inflammation in rheumatoid arthritis (RA), utilizing magnetic resonance imaging (MRI).METHODS: Gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI was performed in 21 patients with knee synovitis. Changes in synovial membrane signal intensity were identified and quantified by line profile analysis. Multiple synovial biopsies were obtained by a blind biopsy technique, and standard clinical and laboratory measurements of disease activity were recorded.RESULTS: The rate of synovial membrane enhancement correlated with histologic features of acute inflammation (r = 0.63, P < 0.01), but not with clinical or laboratory assessments.CONCLUSION: Dynamic MRI is a valuable technique for assessing acute synovial inflammation in RA.

AB - OBJECTIVE: To develop a method for quantifying acute synovial inflammation in rheumatoid arthritis (RA), utilizing magnetic resonance imaging (MRI).METHODS: Gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI was performed in 21 patients with knee synovitis. Changes in synovial membrane signal intensity were identified and quantified by line profile analysis. Multiple synovial biopsies were obtained by a blind biopsy technique, and standard clinical and laboratory measurements of disease activity were recorded.RESULTS: The rate of synovial membrane enhancement correlated with histologic features of acute inflammation (r = 0.63, P < 0.01), but not with clinical or laboratory assessments.CONCLUSION: Dynamic MRI is a valuable technique for assessing acute synovial inflammation in RA.

KW - Adult

KW - Aged

KW - Arthritis, Rheumatoid/complications

KW - Contrast Media

KW - Female

KW - Gadolinium DTPA

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Organometallic Compounds

KW - Pentetic Acid/analogs & derivatives

KW - Synovitis/complications

U2 - 10.1002/art.1780381113

DO - 10.1002/art.1780381113

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