Quantification of rheumatoid synovitis by magnetic resonance imaging

Karl Gaffney, John Cookson, David Blake, Adam Coumbe, Selina Blades

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OBJECTIVE: To develop a method for quantifying acute synovial inflammation in rheumatoid arthritis (RA), utilizing magnetic resonance imaging (MRI).

METHODS: Gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI was performed in 21 patients with knee synovitis. Changes in synovial membrane signal intensity were identified and quantified by line profile analysis. Multiple synovial biopsies were obtained by a blind biopsy technique, and standard clinical and laboratory measurements of disease activity were recorded.

RESULTS: The rate of synovial membrane enhancement correlated with histologic features of acute inflammation (r = 0.63, P < 0.01), but not with clinical or laboratory assessments.

CONCLUSION: Dynamic MRI is a valuable technique for assessing acute synovial inflammation in RA.

Original languageEnglish
Pages (from-to)1610-1617
Number of pages8
JournalArthritis and Rheumatism
Issue number11
Publication statusPublished - Nov 1995
Externally publishedYes


  • Adult
  • Aged
  • Arthritis, Rheumatoid/complications
  • Contrast Media
  • Female
  • Gadolinium DTPA
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Organometallic Compounds
  • Pentetic Acid/analogs & derivatives
  • Synovitis/complications

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