Radial artery pulse wave analysis for non-invasive assessment of coronary artery disease

Dipak Kotecha; Gishel New; Peter Collins; David Eccleston; Henry Krum; John Pepper; Marcus D. Flather

doi:10.1016/j.ijcard.2012.03.098

Radial artery pulse wave analysis for non-invasive assessment of coronary artery disease

Dipak Kotecha, Gishel New, Peter Collins, David Eccleston, Henry Krum, John Pepper, Marcus D. Flather

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: Angiographically-normal coronary arteries are reported in 10-20% of patients undergoing diagnostic coronary angiography despite screening with risk factors and functional tests. We sought to validate and determine the clinical value of radial artery pulse wave analysis (PWA), a simple, quick and non-invasive marker of central artery stiffness and define its ability to predict coronary artery disease in high-risk patients. MATERIALS AND METHODS: 531 consecutive patients referred for elective coronary angiography, irrespective of previous co-morbidity, were assessed in a prospective, multicenter observational study [the Alternative Risk Markers in Coronary Artery Disease (ARM-CAD) study]. RESULTS: Mean age was 65±11years, 33% were women, 18% had impaired left-ventricular function and 22% a prior myocardial infarction. Angiography demonstrated normal coronary arteries in 20% of participants. The only independent associations with this outcome were younger age, female gender, absence of diabetes and PWA-derived central augmentation pressure

Original language	English
Pages (from-to)	917–924
Number of pages	8
Journal	International Journal of Cardiology
Volume	167
Issue number	3
DOIs	https://doi.org/10.1016/j.ijcard.2012.03.098
Publication status	Published - 10 Aug 2013

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10.1016/j.ijcard.2012.03.098

Cite this

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title = "Radial artery pulse wave analysis for non-invasive assessment of coronary artery disease",

abstract = "BACKGROUND: Angiographically-normal coronary arteries are reported in 10-20% of patients undergoing diagnostic coronary angiography despite screening with risk factors and functional tests. We sought to validate and determine the clinical value of radial artery pulse wave analysis (PWA), a simple, quick and non-invasive marker of central artery stiffness and define its ability to predict coronary artery disease in high-risk patients. MATERIALS AND METHODS: 531 consecutive patients referred for elective coronary angiography, irrespective of previous co-morbidity, were assessed in a prospective, multicenter observational study [the Alternative Risk Markers in Coronary Artery Disease (ARM-CAD) study]. RESULTS: Mean age was 65±11years, 33% were women, 18% had impaired left-ventricular function and 22% a prior myocardial infarction. Angiography demonstrated normal coronary arteries in 20% of participants. The only independent associations with this outcome were younger age, female gender, absence of diabetes and PWA-derived central augmentation pressure ",

author = "Dipak Kotecha and Gishel New and Peter Collins and David Eccleston and Henry Krum and John Pepper and Flather, {Marcus D.}",

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doi = "10.1016/j.ijcard.2012.03.098",

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T1 - Radial artery pulse wave analysis for non-invasive assessment of coronary artery disease

AU - Kotecha, Dipak

AU - New, Gishel

AU - Collins, Peter

AU - Eccleston, David

AU - Krum, Henry

AU - Pepper, John

AU - Flather, Marcus D.

PY - 2013/8/10

Y1 - 2013/8/10

N2 - BACKGROUND: Angiographically-normal coronary arteries are reported in 10-20% of patients undergoing diagnostic coronary angiography despite screening with risk factors and functional tests. We sought to validate and determine the clinical value of radial artery pulse wave analysis (PWA), a simple, quick and non-invasive marker of central artery stiffness and define its ability to predict coronary artery disease in high-risk patients. MATERIALS AND METHODS: 531 consecutive patients referred for elective coronary angiography, irrespective of previous co-morbidity, were assessed in a prospective, multicenter observational study [the Alternative Risk Markers in Coronary Artery Disease (ARM-CAD) study]. RESULTS: Mean age was 65±11years, 33% were women, 18% had impaired left-ventricular function and 22% a prior myocardial infarction. Angiography demonstrated normal coronary arteries in 20% of participants. The only independent associations with this outcome were younger age, female gender, absence of diabetes and PWA-derived central augmentation pressure

AB - BACKGROUND: Angiographically-normal coronary arteries are reported in 10-20% of patients undergoing diagnostic coronary angiography despite screening with risk factors and functional tests. We sought to validate and determine the clinical value of radial artery pulse wave analysis (PWA), a simple, quick and non-invasive marker of central artery stiffness and define its ability to predict coronary artery disease in high-risk patients. MATERIALS AND METHODS: 531 consecutive patients referred for elective coronary angiography, irrespective of previous co-morbidity, were assessed in a prospective, multicenter observational study [the Alternative Risk Markers in Coronary Artery Disease (ARM-CAD) study]. RESULTS: Mean age was 65±11years, 33% were women, 18% had impaired left-ventricular function and 22% a prior myocardial infarction. Angiography demonstrated normal coronary arteries in 20% of participants. The only independent associations with this outcome were younger age, female gender, absence of diabetes and PWA-derived central augmentation pressure

U2 - 10.1016/j.ijcard.2012.03.098

DO - 10.1016/j.ijcard.2012.03.098

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JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 1874-1754

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