Radiolabeled leucocyte imaging in diffuse granulomatous involvement of the meninges in Wegener's granulomatosis: scintigraphic findings and their role in monitoring treatment response to specific immunotherapy (humanized monoclonal antilymphocyte antibodies)

Joseph M. Murphy, Kottekkattu K. Balan, Andoni Toms, Beatriz Gomez-Anson, Martin Lockwood

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Diffuse involvement of the meninges by remote granulomas in Wegener's granulomatosis is rare. This study reports the radiolabeled leucocyte imaging findings in five such patients. The diagnosis was made by MR imaging in five patients and confirmed in four by findings at meningeal biopsy. The potential role of serial radiolabeled leucocyte examinations in assessing treatment response is discussed.
Original languageEnglish
Pages (from-to)1460-1465
Number of pages6
JournalAmerican Journal of Neuroradiology
Issue number8
Publication statusPublished - Sep 2000


  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Antilymphocyte Serum
  • Female
  • Humans
  • Immunotherapy
  • Indium Radioisotopes
  • Leukocytes
  • Magnetic Resonance Imaging
  • Male
  • Meninges
  • Middle Aged
  • Radiopharmaceuticals
  • Technetium Tc 99m Exametazime
  • Wegener Granulomatosis

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