Abstract
The commensal intestinal microbiota drive the inflammation associated with Crohn's disease. However, bacteria such as bifidobacteria and Faecalibacterium prausnitzii appear to be immunoregulatory. In healthy subjects the intestinal microbiota are influenced by prebiotic carbohydrates such as fructo-oligosaccharides (FOS). Preliminary data suggest that FOS increase faecal bifidobacteria, induce immunoregulatory dendritic cell (DC) responses and reduce disease activity in patients with Crohn's disease.
Original language | English |
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Pages (from-to) | 923-9 |
Number of pages | 7 |
Journal | Gut |
Volume | 60 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2011 |
Keywords
- Adult
- Bifidobacterium
- Crohn Disease
- Dendritic Cells
- Double-Blind Method
- Feces
- Female
- Humans
- Immunity, Mucosal
- Intestinal Mucosa
- Male
- Medication Adherence
- Middle Aged
- Oligosaccharides
- Prebiotics
- Rectum
- Treatment Outcome