Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis

Keith Leiper; Kate Martin; Anthony Ellis; Sreedhar Subramanian; Alastair J Watson; Steve E Christmas; Deborah Howarth; Fiona Campbell; Jonathan M Rhodes

doi:10.1136/gut.2010.225482

Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis

Keith Leiper, Kate Martin, Anthony Ellis, Sreedhar Subramanian, Alastair J Watson, Steve E Christmas, Deborah Howarth, Fiona Campbell, Jonathan M Rhodes

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

To assess the safety and efficacy of the B lymphocyte (anti-CD20) antibody, rituximab, in the treatment of steroid-resistant moderately active ulcerative colitis (UC).

Original language	English
Pages (from-to)	1520-1526
Number of pages	7
Journal	Gut
Volume	60
Issue number	11
DOIs	https://doi.org/10.1136/gut.2010.225482
Publication status	Published - Nov 2011

Keywords

Adult
Antibodies, Monoclonal, Murine-Derived
Antigens, CD19
Antigens, CD20
B-Lymphocytes
Colitis, Ulcerative
Colon
Female
Glucocorticoids
Humans
Immunohistochemistry
Immunosuppressive Agents
Lymphocyte Count
Middle Aged
Remission Induction

Access to Document

10.1136/gut.2010.225482

Cite this

@article{a5e62024342441dfbc191c6a011c940c,

title = "Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis",

abstract = "To assess the safety and efficacy of the B lymphocyte (anti-CD20) antibody, rituximab, in the treatment of steroid-resistant moderately active ulcerative colitis (UC).",

keywords = "Adult, Antibodies, Monoclonal, Murine-Derived, Antigens, CD19, Antigens, CD20, B-Lymphocytes, Colitis, Ulcerative, Colon, Female, Glucocorticoids, Humans, Immunohistochemistry, Immunosuppressive Agents, Lymphocyte Count, Middle Aged, Remission Induction",

author = "Keith Leiper and Kate Martin and Anthony Ellis and Sreedhar Subramanian and Watson, {Alastair J} and Christmas, {Steve E} and Deborah Howarth and Fiona Campbell and Rhodes, {Jonathan M}",

year = "2011",

month = nov,

doi = "10.1136/gut.2010.225482",

language = "English",

volume = "60",

pages = "1520--1526",

journal = "Gut",

issn = "0017-5749",

publisher = "BMJ Publishing Group",

number = "11",

}

TY - JOUR

T1 - Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis

AU - Leiper, Keith

AU - Martin, Kate

AU - Ellis, Anthony

AU - Subramanian, Sreedhar

AU - Watson, Alastair J

AU - Christmas, Steve E

AU - Howarth, Deborah

AU - Campbell, Fiona

AU - Rhodes, Jonathan M

PY - 2011/11

Y1 - 2011/11

N2 - To assess the safety and efficacy of the B lymphocyte (anti-CD20) antibody, rituximab, in the treatment of steroid-resistant moderately active ulcerative colitis (UC).

AB - To assess the safety and efficacy of the B lymphocyte (anti-CD20) antibody, rituximab, in the treatment of steroid-resistant moderately active ulcerative colitis (UC).

KW - Adult

KW - Antibodies, Monoclonal, Murine-Derived

KW - Antigens, CD19

KW - Antigens, CD20

KW - B-Lymphocytes

KW - Colitis, Ulcerative

KW - Colon

KW - Female

KW - Glucocorticoids

KW - Humans

KW - Immunohistochemistry

KW - Immunosuppressive Agents

KW - Lymphocyte Count

KW - Middle Aged

KW - Remission Induction

U2 - 10.1136/gut.2010.225482

DO - 10.1136/gut.2010.225482

M3 - Article

C2 - 21471566

VL - 60

SP - 1520

EP - 1526

JO - Gut

JF - Gut

SN - 0017-5749

IS - 11

ER -