Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot)

Sonya V Babu-Narayan, Anselm Uebing, Periklis A Davlouros, Michael Kemp, Simon Davidson, Konstantinos Dimopoulos, Stephanie Bayne, Dudley J Pennell, Derek G Gibson, Marcus Flather, Philip J Kilner, Wei Li, Michael A Gatzoulis

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86 Citations (Scopus)


Optimal treatment for stable repaired tetralogy of Fallot (rTOF) patients with pulmonary regurgitation (PR) and related right ventricular (RV) dilatation, including timing of valve implantation, remains uncertain. We sought to study tolerability of the angiotensin-converting-enzyme (ACE) inhibitor ramipril and its effects on cardiovascular function in these patients.
Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalInternational Journal of Cardiology
Issue number3
Publication statusPublished - 9 Feb 2012


  • Angiotensin-Converting Enzyme Inhibitors
  • Double-Blind Method
  • Feasibility Studies
  • Humans
  • Prospective Studies
  • Pulmonary Valve Insufficiency
  • Ramipril
  • Tetralogy of Fallot
  • Time Factors
  • Ventricular Function

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