Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot)

Sonya V Babu-Narayan; Anselm Uebing; Periklis A Davlouros; Michael Kemp; Simon Davidson; Konstantinos Dimopoulos; Stephanie Bayne; Dudley J Pennell; Derek G Gibson; Marcus Flather; Philip J Kilner; Wei Li; Michael A Gatzoulis

doi:10.1016/j.ijcard.2010.09.057

Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot)

Sonya V Babu-Narayan, Anselm Uebing, Periklis A Davlouros, Michael Kemp, Simon Davidson, Konstantinos Dimopoulos, Stephanie Bayne, Dudley J Pennell, Derek G Gibson, Marcus Flather, Philip J Kilner, Wei Li, Michael A Gatzoulis

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

Optimal treatment for stable repaired tetralogy of Fallot (rTOF) patients with pulmonary regurgitation (PR) and related right ventricular (RV) dilatation, including timing of valve implantation, remains uncertain. We sought to study tolerability of the angiotensin-converting-enzyme (ACE) inhibitor ramipril and its effects on cardiovascular function in these patients.

Original language	English
Pages (from-to)	299-305
Number of pages	7
Journal	International Journal of Cardiology
Volume	154
Issue number	3
DOIs	https://doi.org/10.1016/j.ijcard.2010.09.057
Publication status	Published - 9 Feb 2012

Keywords

Angiotensin-Converting Enzyme Inhibitors
Double-Blind Method
Feasibility Studies
Humans
Prospective Studies
Pulmonary Valve Insufficiency
Ramipril
Tetralogy of Fallot
Time Factors
Ventricular Function

Access to Document

10.1016/j.ijcard.2010.09.057

Cite this

Babu-Narayan, S. V., Uebing, A., Davlouros, P. A., Kemp, M., Davidson, S., Dimopoulos, K., Bayne, S., Pennell, D. J., Gibson, D. G., Flather, M., Kilner, P. J., Li, W., & Gatzoulis, M. A. (2012). Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot). International Journal of Cardiology, 154(3), 299-305. https://doi.org/10.1016/j.ijcard.2010.09.057

Babu-Narayan, Sonya V ; Uebing, Anselm ; Davlouros, Periklis A et al. / Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation : the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot). In: International Journal of Cardiology. 2012 ; Vol. 154, No. 3. pp. 299-305.

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title = "Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot)",

abstract = "Optimal treatment for stable repaired tetralogy of Fallot (rTOF) patients with pulmonary regurgitation (PR) and related right ventricular (RV) dilatation, including timing of valve implantation, remains uncertain. We sought to study tolerability of the angiotensin-converting-enzyme (ACE) inhibitor ramipril and its effects on cardiovascular function in these patients.",

keywords = "Angiotensin-Converting Enzyme Inhibitors, Double-Blind Method, Feasibility Studies, Humans, Prospective Studies, Pulmonary Valve Insufficiency, Ramipril, Tetralogy of Fallot, Time Factors, Ventricular Function",

author = "Babu-Narayan, {Sonya V} and Anselm Uebing and Davlouros, {Periklis A} and Michael Kemp and Simon Davidson and Konstantinos Dimopoulos and Stephanie Bayne and Pennell, {Dudley J} and Gibson, {Derek G} and Marcus Flather and Kilner, {Philip J} and Wei Li and Gatzoulis, {Michael A}",

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Babu-Narayan, SV, Uebing, A, Davlouros, PA, Kemp, M, Davidson, S, Dimopoulos, K, Bayne, S, Pennell, DJ, Gibson, DG, Flather, M, Kilner, PJ, Li, W & Gatzoulis, MA 2012, 'Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot)', International Journal of Cardiology, vol. 154, no. 3, pp. 299-305. https://doi.org/10.1016/j.ijcard.2010.09.057

Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation : the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot). / Babu-Narayan, Sonya V; Uebing, Anselm; Davlouros, Periklis A et al.

In: International Journal of Cardiology, Vol. 154, No. 3, 09.02.2012, p. 299-305.

Research output: Contribution to journal › Article › peer-review

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T1 - Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation

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AU - Babu-Narayan, Sonya V

AU - Uebing, Anselm

AU - Davlouros, Periklis A

AU - Kemp, Michael

AU - Davidson, Simon

AU - Dimopoulos, Konstantinos

AU - Bayne, Stephanie

AU - Pennell, Dudley J

AU - Gibson, Derek G

AU - Flather, Marcus

AU - Kilner, Philip J

AU - Li, Wei

AU - Gatzoulis, Michael A

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AB - Optimal treatment for stable repaired tetralogy of Fallot (rTOF) patients with pulmonary regurgitation (PR) and related right ventricular (RV) dilatation, including timing of valve implantation, remains uncertain. We sought to study tolerability of the angiotensin-converting-enzyme (ACE) inhibitor ramipril and its effects on cardiovascular function in these patients.

KW - Angiotensin-Converting Enzyme Inhibitors

KW - Double-Blind Method

KW - Feasibility Studies

KW - Humans

KW - Prospective Studies

KW - Pulmonary Valve Insufficiency

KW - Ramipril

KW - Tetralogy of Fallot

KW - Time Factors

KW - Ventricular Function

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Babu-Narayan SV, Uebing A, Davlouros PA, Kemp M, Davidson S, Dimopoulos K et al. Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot). International Journal of Cardiology. 2012 Feb 9;154(3):299-305. doi: 10.1016/j.ijcard.2010.09.057