Randomized, placebo-controlled trial of gastric acid-lowering therapy on duodenal polyposis and relative adduct labeling in familial adenomatous polyposis

Marina H. Wallace, Alastair Forbes, Iain G. Beveridge, Allan D. Spigelman, Alan Hewer, Stan Venitt, Robin K. S. Phillips

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18 Citations (Scopus)


Bile has been implicated in the pathogenesis of duodenal polyps in patients with familial adenomatous polyposis. In vitro experiments have shown that familial adenomatous polyposis bile is capable of producing DNA adducts. This effect can be ameliorated by increasing the pH of the incubate. The aim of this double-blind randomized placebo-controlled trial was to examine the effect of oral ranitidine on duodenal polyposis in a group of patients with familial adenomatous polyposis.
Original languageEnglish
Pages (from-to)1585-9
Number of pages5
JournalDiseases of the Colon and Rectum
Issue number11
Publication statusPublished - Nov 2001


  • Adenomatous Polyposis Coli
  • Administration, Oral
  • Adult
  • Anti-Ulcer Agents
  • Bile
  • DNA Adducts
  • Double-Blind Method
  • Duodenal Neoplasms
  • Endoscopy
  • Female
  • Gastric Acid
  • Humans
  • Intestinal Polyps
  • Male
  • Ranitidine
  • Treatment Outcome

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