Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease Trial

Stephen D Wiviott; Marcus D Flather; Michelle L O'Donoghue; Shinya Goto; Desmond J Fitzgerald; Fernando Cura; Philip Aylward; Victor Guetta; Dariusz Dudek; Charles F Contant; Dominick J Angiolillo; Deepak L Bhatt; LANCELOT-CAD Investigators

doi:10.1161/CIRCULATIONAHA.110.001404

Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease Trial

Stephen D Wiviott
, Marcus D Flather
, Michelle L O'Donoghue
, Shinya Goto
, Desmond J Fitzgerald
, Fernando Cura
, Philip Aylward
, Victor Guetta
, Dariusz Dudek
, Charles F Contant
, Dominick J Angiolillo
, Deepak L Bhatt
, LANCELOT-CAD Investigators

Research output: Contribution to journal › Article › peer-review

Abstract

Thrombin is a key mediator of platelet activation. Atopaxar is a reversible protease-activated receptor-1 antagonist that interferes with thrombin-mediated platelet effects. The phase II Lessons From Antagonizing the Cellular Effect of Thrombin-Coronary Artery Disease (LANCELOT-CAD) trial examined the safety and tolerability of prolonged therapy with atopaxar in subjects with CAD.

Original language	English
Pages (from-to)	1854-63
Number of pages	10
Journal	Circulation
Volume	123
Issue number	17
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.110.001404
Publication status	Published - 3 May 2011

Keywords

Aged
Biological Markers
Blood Platelets
Coronary Artery Disease
Dose-Response Relationship, Drug
Female
Hemorrhage
Humans
Imines
Male
Middle Aged
Platelet Activation
Platelet Aggregation Inhibitors
Pyridines
Receptors, Thrombin

Access to Document

10.1161/CIRCULATIONAHA.110.001404

Cite this

Wiviott, S. D., Flather, M. D., O'Donoghue, M. L., Goto, S., Fitzgerald, D. J., Cura, F., Aylward, P., Guetta, V., Dudek, D., Contant, C. F., Angiolillo, D. J., Bhatt, D. L., & LANCELOT-CAD Investigators (2011). Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease Trial. Circulation, 123(17), 1854-63. https://doi.org/10.1161/CIRCULATIONAHA.110.001404

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title = "Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease Trial",

abstract = "Thrombin is a key mediator of platelet activation. Atopaxar is a reversible protease-activated receptor-1 antagonist that interferes with thrombin-mediated platelet effects. The phase II Lessons From Antagonizing the Cellular Effect of Thrombin-Coronary Artery Disease (LANCELOT-CAD) trial examined the safety and tolerability of prolonged therapy with atopaxar in subjects with CAD.",

keywords = "Aged, Biological Markers, Blood Platelets, Coronary Artery Disease, Dose-Response Relationship, Drug, Female, Hemorrhage, Humans, Imines, Male, Middle Aged, Platelet Activation, Platelet Aggregation Inhibitors, Pyridines, Receptors, Thrombin",

author = "Wiviott, \{Stephen D\} and Flather, \{Marcus D\} and O'Donoghue, \{Michelle L\} and Shinya Goto and Fitzgerald, \{Desmond J\} and Fernando Cura and Philip Aylward and Victor Guetta and Dariusz Dudek and Contant, \{Charles F\} and Angiolillo, \{Dominick J\} and Bhatt, \{Deepak L\} and \{LANCELOT-CAD Investigators\}",

year = "2011",

month = may,

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doi = "10.1161/CIRCULATIONAHA.110.001404",

language = "English",

volume = "123",

pages = "1854--63",

journal = "Circulation",

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Wiviott, SD, Flather, MD, O'Donoghue, ML, Goto, S, Fitzgerald, DJ, Cura, F, Aylward, P, Guetta, V, Dudek, D, Contant, CF, Angiolillo, DJ, Bhatt, DL & LANCELOT-CAD Investigators 2011, 'Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease Trial', Circulation, vol. 123, no. 17, pp. 1854-63. https://doi.org/10.1161/CIRCULATIONAHA.110.001404

Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease Trial. / Wiviott, Stephen D; Flather, Marcus D; O'Donoghue, Michelle L et al.
In: Circulation, Vol. 123, No. 17, 03.05.2011, p. 1854-63.

Research output: Contribution to journal › Article › peer-review

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