Rapid detection of sildenafil analogue in Eurycoma longifolia products using a new two-tier procedure of the near infrared (NIR) spectra database

Mazlina Mohd Said; Simon Gibbons; Anthony C. Moffat; Mire Zloh

doi:10.1016/j.foodchem.2014.02.125

Rapid detection of sildenafil analogue in Eurycoma longifolia products using a new two-tier procedure of the near infrared (NIR) spectra database

Mazlina Mohd Said, Simon Gibbons, Anthony C. Moffat, Mire Zloh

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A simple and cost-effective two-tier drug screening procedure comprises a 'dedicated' NIR spectral database of common medicines and a 'unified' database was developed to detect the sildenafil analogue in Eurycoma longifolia products. Diffuse reflectance spectra of ten commercial herbal products containing E. longifolia were obtained over the wavelength range of 1100-2500 nm. The spectral search of two products purchased via the internet against a dedicated database of reputable E. longifolia products have resulted in the similarity index of more than 0.1 which indicated significantly different spectra. Further searches against the unified database showed a close match to the spectra of drug containing sildenafil citrate suggesting the presence of a sildenafil analogue. This finding was supported by clustering of these spectra in the PCA score plot within 5 2014 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	296-301
Number of pages	6
Journal	Food Chemistry
Volume	158
Early online date	6 Mar 2014
DOIs	https://doi.org/10.1016/j.foodchem.2014.02.125
Publication status	Published - 1 Sep 2014

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10.1016/j.foodchem.2014.02.125

Cite this

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title = "Rapid detection of sildenafil analogue in Eurycoma longifolia products using a new two-tier procedure of the near infrared (NIR) spectra database",

abstract = "A simple and cost-effective two-tier drug screening procedure comprises a 'dedicated' NIR spectral database of common medicines and a 'unified' database was developed to detect the sildenafil analogue in Eurycoma longifolia products. Diffuse reflectance spectra of ten commercial herbal products containing E. longifolia were obtained over the wavelength range of 1100-2500 nm. The spectral search of two products purchased via the internet against a dedicated database of reputable E. longifolia products have resulted in the similarity index of more than 0.1 which indicated significantly different spectra. Further searches against the unified database showed a close match to the spectra of drug containing sildenafil citrate suggesting the presence of a sildenafil analogue. This finding was supported by clustering of these spectra in the PCA score plot within 5 2014 Elsevier Ltd. All rights reserved.",

author = "Said, {Mazlina Mohd} and Simon Gibbons and Moffat, {Anthony C.} and Mire Zloh",

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AU - Said, Mazlina Mohd

AU - Gibbons, Simon

AU - Moffat, Anthony C.

AU - Zloh, Mire

PY - 2014/9/1

Y1 - 2014/9/1

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AB - A simple and cost-effective two-tier drug screening procedure comprises a 'dedicated' NIR spectral database of common medicines and a 'unified' database was developed to detect the sildenafil analogue in Eurycoma longifolia products. Diffuse reflectance spectra of ten commercial herbal products containing E. longifolia were obtained over the wavelength range of 1100-2500 nm. The spectral search of two products purchased via the internet against a dedicated database of reputable E. longifolia products have resulted in the similarity index of more than 0.1 which indicated significantly different spectra. Further searches against the unified database showed a close match to the spectra of drug containing sildenafil citrate suggesting the presence of a sildenafil analogue. This finding was supported by clustering of these spectra in the PCA score plot within 5 2014 Elsevier Ltd. All rights reserved.

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DO - 10.1016/j.foodchem.2014.02.125

M3 - Article

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EP - 301

JO - Food Chemistry

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