Rationalising the effect of reducing agent on the oxazaborolidine-mediated asymmetric reduction of N-substituted imines

Eirene H. M. Kirton; Gary Tughan; Russell E. Morris; Robert A. Field

doi:10.1016/j.tetlet.2003.11.021

Rationalising the effect of reducing agent on the oxazaborolidine-mediated asymmetric reduction of N-substituted imines

Eirene H. M. Kirton
, Gary Tughan
, Russell E. Morris
, Robert A. Field

School of Chemistry, Pharmacy and Pharmacology

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Comparing the effect of borane-based reducing agents on the stereochemical outcome of oxazaborolidine-mediated ketone and N-substituted imine reduction highlights the potential importance of reducing agent structure on the asymmetric sense of imine reduction.

Original language	English
Pages (from-to)	853-855
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	4
Early online date	3 Dec 2003
DOIs	https://doi.org/10.1016/j.tetlet.2003.11.021
Publication status	Published - 19 Jan 2004

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10.1016/j.tetlet.2003.11.021

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title = "Rationalising the effect of reducing agent on the oxazaborolidine-mediated asymmetric reduction of N-substituted imines",

abstract = "Comparing the effect of borane-based reducing agents on the stereochemical outcome of oxazaborolidine-mediated ketone and N-substituted imine reduction highlights the potential importance of reducing agent structure on the asymmetric sense of imine reduction.",

author = "Kirton, \{Eirene H. M.\} and Gary Tughan and Morris, \{Russell E.\} and Field, \{Robert A.\}",

note = "Funding Information: This study was supported by EPSRC and GSK (CASE award to E.H.M.K.). ",

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AU - Kirton, Eirene H. M.

AU - Tughan, Gary

AU - Morris, Russell E.

AU - Field, Robert A.

N1 - Funding Information: This study was supported by EPSRC and GSK (CASE award to E.H.M.K.).

PY - 2004/1/19

Y1 - 2004/1/19

N2 - Comparing the effect of borane-based reducing agents on the stereochemical outcome of oxazaborolidine-mediated ketone and N-substituted imine reduction highlights the potential importance of reducing agent structure on the asymmetric sense of imine reduction.

AB - Comparing the effect of borane-based reducing agents on the stereochemical outcome of oxazaborolidine-mediated ketone and N-substituted imine reduction highlights the potential importance of reducing agent structure on the asymmetric sense of imine reduction.

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U2 - 10.1016/j.tetlet.2003.11.021

DO - 10.1016/j.tetlet.2003.11.021

M3 - Article

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SN - 0040-4039

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SP - 853

EP - 855

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

Rationalising the effect of reducing agent on the oxazaborolidine-mediated asymmetric reduction of N-substituted imines

Abstract

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