Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia coli

Kenji Watanabe, Kinya Hotta, Alex P. Praseuth, Mark Searcey, Clay C. C. Wang, Hiroki Oguri, Hideaki Oikawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Drugs from bugs. We have successfully expanded the scope of our E. coli-based total biosynthesis of natural products and their analogues by rationally engineering the echinomycin biosynthesis pathway for the production of a synthetic analogue of triostin A, TANDEM; this demonstrates the amenability of the biosynthesis enzymes and E. coli towards further engineering.
Original languageEnglish
Pages (from-to)1965-1968
Number of pages4
JournalChemBioChem
Volume10
Issue number12
DOIs
Publication statusPublished - 17 Aug 2009

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