Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli

Kenji Watanabe; Kinya Hotta; Alex P. Praseuth; Mark Searcey; Clay C. C. Wang; Hiroki Oguri; Hideaki Oikawa

doi:10.1002/cbic.200900260

Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli

Kenji Watanabe, Kinya Hotta, Alex P. Praseuth, Mark Searcey, Clay C. C. Wang, Hiroki Oguri, Hideaki Oikawa

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Drugs from bugs. We have successfully expanded the scope of our E. coli-based total biosynthesis of natural products and their analogues by rationally engineering the echinomycin biosynthesis pathway for the production of a synthetic analogue of triostin A, TANDEM; this demonstrates the amenability of the biosynthesis enzymes and E. coli towards further engineering.

Original language	English
Pages (from-to)	1965-1968
Number of pages	4
Journal	ChemBioChem
Volume	10
Issue number	12
DOIs	https://doi.org/10.1002/cbic.200900260
Publication status	Published - 17 Aug 2009

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10.1002/cbic.200900260

Cite this

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title = "Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli",

abstract = "Drugs from bugs. We have successfully expanded the scope of our E. coli-based total biosynthesis of natural products and their analogues by rationally engineering the echinomycin biosynthesis pathway for the production of a synthetic analogue of triostin A, TANDEM; this demonstrates the amenability of the biosynthesis enzymes and E. coli towards further engineering.",

author = "Kenji Watanabe and Kinya Hotta and Praseuth, {Alex P.} and Mark Searcey and Wang, {Clay C. C.} and Hiroki Oguri and Hideaki Oikawa",

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AU - Praseuth, Alex P.

AU - Searcey, Mark

AU - Wang, Clay C. C.

AU - Oguri, Hiroki

AU - Oikawa, Hideaki

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AB - Drugs from bugs. We have successfully expanded the scope of our E. coli-based total biosynthesis of natural products and their analogues by rationally engineering the echinomycin biosynthesis pathway for the production of a synthetic analogue of triostin A, TANDEM; this demonstrates the amenability of the biosynthesis enzymes and E. coli towards further engineering.

U2 - 10.1002/cbic.200900260

DO - 10.1002/cbic.200900260

M3 - Article

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EP - 1968

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JF - ChemBioChem

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