Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli

Kenji Watanabe, Kinya Hotta, Alex P. Praseuth, Mark Searcey, Clay C. C. Wang, Hiroki Oguri, Hideaki Oikawa

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Drugs from bugs. We have successfully expanded the scope of our E. coli-based total biosynthesis of natural products and their analogues by rationally engineering the echinomycin biosynthesis pathway for the production of a synthetic analogue of triostin A, TANDEM; this demonstrates the amenability of the biosynthesis enzymes and E. coli towards further engineering.
Original languageEnglish
Pages (from-to)1965-1968
Number of pages4
Issue number12
Publication statusPublished - 17 Aug 2009

Cite this