Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity

Helen M. Sheldrake; Sandra Travica; Inger Johansson; Paul M. Loadman; Mark Sutherland; Lina Elsalem; Nicola Illingworth; Alexander J. Cresswell; Tristan Reuillon; Steven D. Shnyder; Souren Mkrtchian; Mark Searcey; Magnus Ingelman-Sundberg; Laurence H. Patterson; Klaus Pors

doi:10.1021/jm4000209

Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity

Helen M. Sheldrake, Sandra Travica, Inger Johansson, Paul M. Loadman, Mark Sutherland, Lina Elsalem, Nicola Illingworth, Alexander J. Cresswell, Tristan Reuillon, Steven D. Shnyder, Souren Mkrtchian, Mark Searcey, Magnus Ingelman-Sundberg, Laurence H. Patterson, Klaus Pors

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Original language	English
Pages (from-to)	6273-6277
Number of pages	5
Journal	Journal of Medicinal Chemistry
Volume	56
Issue number	15
DOIs	https://doi.org/10.1021/jm4000209
Publication status	Published - 11 Jul 2013

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10.1021/jm4000209

Cite this

Sheldrake, H. M., Travica, S., Johansson, I., Loadman, P. M., Sutherland, M., Elsalem, L., Illingworth, N., Cresswell, A. J., Reuillon, T., Shnyder, S. D., Mkrtchian, S., Searcey, M., Ingelman-Sundberg, M., Patterson, L. H., & Pors, K. (2013). Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity. Journal of Medicinal Chemistry, 56(15), 6273-6277. https://doi.org/10.1021/jm4000209

Sheldrake, Helen M. ; Travica, Sandra ; Johansson, Inger ; Loadman, Paul M. ; Sutherland, Mark ; Elsalem, Lina ; Illingworth, Nicola ; Cresswell, Alexander J. ; Reuillon, Tristan ; Shnyder, Steven D. ; Mkrtchian, Souren ; Searcey, Mark ; Ingelman-Sundberg, Magnus ; Patterson, Laurence H. ; Pors, Klaus. / Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity. In: Journal of Medicinal Chemistry. 2013 ; Vol. 56, No. 15. pp. 6273-6277.

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title = "Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity",

author = "Sheldrake, {Helen M.} and Sandra Travica and Inger Johansson and Loadman, {Paul M.} and Mark Sutherland and Lina Elsalem and Nicola Illingworth and Cresswell, {Alexander J.} and Tristan Reuillon and Shnyder, {Steven D.} and Souren Mkrtchian and Mark Searcey and Magnus Ingelman-Sundberg and Patterson, {Laurence H.} and Klaus Pors",

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Sheldrake, HM, Travica, S, Johansson, I, Loadman, PM, Sutherland, M, Elsalem, L, Illingworth, N, Cresswell, AJ, Reuillon, T, Shnyder, SD, Mkrtchian, S, Searcey, M, Ingelman-Sundberg, M, Patterson, LH & Pors, K 2013, 'Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity', Journal of Medicinal Chemistry, vol. 56, no. 15, pp. 6273-6277. https://doi.org/10.1021/jm4000209

Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity. / Sheldrake, Helen M.; Travica, Sandra; Johansson, Inger; Loadman, Paul M.; Sutherland, Mark; Elsalem, Lina; Illingworth, Nicola; Cresswell, Alexander J.; Reuillon, Tristan; Shnyder, Steven D.; Mkrtchian, Souren; Searcey, Mark; Ingelman-Sundberg, Magnus; Patterson, Laurence H.; Pors, Klaus.

In: Journal of Medicinal Chemistry, Vol. 56, No. 15, 11.07.2013, p. 6273-6277.

Research output: Contribution to journal › Article › peer-review

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T1 - Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity

AU - Sheldrake, Helen M.

AU - Travica, Sandra

AU - Johansson, Inger

AU - Loadman, Paul M.

AU - Sutherland, Mark

AU - Elsalem, Lina

AU - Illingworth, Nicola

AU - Cresswell, Alexander J.

AU - Reuillon, Tristan

AU - Shnyder, Steven D.

AU - Mkrtchian, Souren

AU - Searcey, Mark

AU - Ingelman-Sundberg, Magnus

AU - Patterson, Laurence H.

AU - Pors, Klaus

PY - 2013/7/11

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U2 - 10.1021/jm4000209

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M3 - Article

VL - 56

SP - 6273

EP - 6277

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

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