Re-evaluation of urinary free metadrenalines reference range

A. S. Davison, A. Banks, G. Higgins, R. Pruden, John Dutton

Research output: Contribution to conferencePosterpeer-review


Diagnosis of phaeochromocytoma can be challenging, current recommendations suggest the measurement of total fractionated urine metadrenalines or plasma free metadrenalines for initial biochemical assessment.1 Few laboratories offer urinary free metadrenalines (UFM) despite them potentially offering greater diagnostic specificity than total fractionated urine metadrenalines. In house urinary free metadrenalines have been available for several years. The rational for perusing this approach is that we believe that the free fraction is the form which is produced directly in the chromaffin cell, though in the chromaffin cell tumour. Therefore it is much more representative than sulphate conjugates which are a product of sulphate transferase 1A3 (SULT1A3) enzyme action in the gastrointestinal tract. The aim of this study was to re-evaluate our current reference ranges in a large local population.
Original languageEnglish
Publication statusPublished - 2014
EventEuroLabFocus - Liverpool, United Kingdom
Duration: 7 Oct 201410 Oct 2014


Country/TerritoryUnited Kingdom

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