TY - JOUR
T1 - Recent developments in molecular sensor designs for inorganic pyrophosphate detection and biological imaging
AU - Anbu, Sellamuthu
AU - Paul, Anup
AU - Stasiuk, Graeme J.
AU - Pombeiro, Armando J.L.
N1 - Funding Information: S.A. gratefully acknowledges the Fundação para a Ciência e Tecnologia (FCT), Portugal, for the award of postdoctoral fellowship (Ref.: SFRH/BPD/76451/2011) and the RSC Research Fund grant (RF19-7464). A.P. is thankful to the FCT and IST, Portugal, for financial support through FCT “DL/57/2017” (Contracts no. IST-ID/197/2019). GJS would like to thank the MRC for funding (MR/T002573/1). This work was also partially supported by the FCT, through project UIDB/00100/2020 of Centro de Química Estrutural.
PY - 2021/3/15
Y1 - 2021/3/15
N2 - Inorganic pyrophosphate (PPi) is a key anion which plays a crucial role in an extensive range of biological and ecological processes. PPi is involved in many physiological reactions, including nucleic acid replication, chromosomal elongation, cell growth, energy storage and transduction, iron delivery, etc. It is the main causative factor for many bone joints diseases (e.g. pseudogout) and eutrophication related ecological issues. In recent years, PPi is conceived as one of the biological markers for various diseases, including cancer and infectious diseases and an essential target in diverse fields including ecological research. The quantification of PPi levels in live cells can offer critical information on metabolic processes, including DNA replication and tumour progression. Thus, development of new chemosensors for PPi opens up the opportunities to identify novel and promising diagnostic reagents for the genetic diseases and the monitoring of intracellular processes. A repertoire of colourimetric and fluorescent chemosensors for PPi has been developed yet, and many of them were not arrayed and explained in such a way to make the readers understand them comparatively. Therefore, in this critical review, we focused onthe design and function of some unsung chemosensors including metal-free, metal-based, sequential sensors, etc. for PPi detection via diverse binding mechanisms reported from 2010 to the end of the year 2019.
AB - Inorganic pyrophosphate (PPi) is a key anion which plays a crucial role in an extensive range of biological and ecological processes. PPi is involved in many physiological reactions, including nucleic acid replication, chromosomal elongation, cell growth, energy storage and transduction, iron delivery, etc. It is the main causative factor for many bone joints diseases (e.g. pseudogout) and eutrophication related ecological issues. In recent years, PPi is conceived as one of the biological markers for various diseases, including cancer and infectious diseases and an essential target in diverse fields including ecological research. The quantification of PPi levels in live cells can offer critical information on metabolic processes, including DNA replication and tumour progression. Thus, development of new chemosensors for PPi opens up the opportunities to identify novel and promising diagnostic reagents for the genetic diseases and the monitoring of intracellular processes. A repertoire of colourimetric and fluorescent chemosensors for PPi has been developed yet, and many of them were not arrayed and explained in such a way to make the readers understand them comparatively. Therefore, in this critical review, we focused onthe design and function of some unsung chemosensors including metal-free, metal-based, sequential sensors, etc. for PPi detection via diverse binding mechanisms reported from 2010 to the end of the year 2019.
KW - Anion sensors
KW - Pyrophosphate
KW - Pyrophosphate imaging
KW - Pyrosequencing
KW - Sequential sensors
UR - http://www.scopus.com/inward/record.url?scp=85099635586&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ccr.2020.213744
DO - https://doi.org/10.1016/j.ccr.2020.213744
M3 - Review article
VL - 431
JO - Coordination Chemistry Review
JF - Coordination Chemistry Review
M1 - 213744
ER -
