Recent developments in the use of glyconanoparticles and related quantum dots for the detection of lectins, viruses, bacteria and cancer cells

Pedro J. Hernando, Simone Dedola, Maria J. Marin, Robert A. Field (Lead Author)

Research output: Contribution to journalArticle

Abstract

Carbohydrate-coated nanoparticles – glyconanoparticles – are finding increased interest as tools in biomedicine. This compilation, mainly covering the past five years, comprises the use of gold, silver and ferrite (magnetic) nanoparticles, silicon-based and cadmium-based quantum dots. Applications in the detection of lectins/protein toxins, viruses and bacteria are covered, as well as advances in detection of cancer cells. The role of the carbohydrate moieties in stabilising nanoparticles and providing selectivity in bioassays is discussed, the issue of cytotoxicity encountered in some systems, especially semiconductor quantum dots, is also considered. Efforts to overcome the latter problem by using other types of nanoparticles, based on gold or silicon, are also presented.
Original languageEnglish
Article number668509
JournalFrontiers in Chemistry
Volume9
DOIs
Publication statusPublished - 19 Jul 2021

Keywords

  • cancer imaging
  • glycobiology
  • glyconanoparticles
  • gold nanoparticles
  • pathogen detection
  • rapid diagnostics

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