Recent progress in the development of small-molecule FtsZ inhibitors as chemical tools for the development of novel antibiotics

Laura Carro

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)
26 Downloads (Pure)

Abstract

Antibiotics are potent pharmacological weapons against bacterial pathogens, nevertheless their efficacy is becoming compromised due to the worldwide emergence and spread of multidrug-resistant bacteria or "superbugs". Antibiotic resistance is rising to such dangerous levels that the treatment of bacterial infections is becoming a clinical challenge. Therefore, urgent action is needed to develop new generations of antibiotics that will help tackle this increasing and serious public health problem. Due to its essential role in bacterial cell division, the tubulin-like protein FtsZ has emerged as a promising target for the development of novel antibiotics with new mechanisms of action. This review highlights the medicinal chemistry efforts towards the identification of small-molecule FtsZ inhibitors with antibacterial activity in the last three years.

Original languageEnglish
Article number217
JournalAntibiotics
Volume8
Issue number4
Early online date11 Nov 2019
DOIs
Publication statusPublished - Dec 2019

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