Reconstructing gene networks: what are the limits?

J Stark, D Brewer, M Barenco, D Tomescu, R Callard, M Hubank

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To fully realize the benefits of high-throughput post-genomic technologies it is necessary to reconstruct and analyse the complicated network of interactions through which most genes operate. We briefly summarize the mathematical frameworks that can be used to model such networks, and the types of algorithms available for their reconstruction. We then focus on dynamic models, typically described using differential equations, and explain the two main reconstruction approaches in current use. We discuss the data requirements of these algorithms and ask how well they correspond to current microarray data.
Original languageEnglish
Pages (from-to)1519-1525
Number of pages7
JournalBiochemical Society Transactions
Volume31
Issue number6
DOIs
Publication statusPublished - Dec 2003

Keywords

  • Genes
  • Mathematics
  • Models, Theoretical
  • Reproducibility of Results

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