Red blood cell nitric oxide as an endocrine vasoregulator: A potential role in congestive heart failure

Borunendra Datta; Timothy Tufnell-Barrett; Robert A. Bleasdale; Christopher J. H. Jones; Ian Beeton; Vincent Paul; Michael Frenneaux; Philip James

doi:10.1161/01.CIR.0000124450.07016.1D

Red blood cell nitric oxide as an endocrine vasoregulator: A potential role in congestive heart failure

Borunendra Datta, Timothy Tufnell-Barrett, Robert A. Bleasdale, Christopher J. H. Jones, Ian Beeton, Vincent Paul, Michael Frenneaux, Philip James

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

A respiratory cycle for nitric oxide (NO) would involve the formation of vasoactive metabolites between NO and hemoglobin during pulmonary oxygenation. We investigated the role of these metabolites in hypoxic tissue in vitro and in vivo in healthy subjects and patients with congestive heart failure (CHF).

Original language	English
Pages (from-to)	1339-1342
Number of pages	4
Journal	Circulation
Volume	109
Issue number	11
DOIs	https://doi.org/10.1161/01.CIR.0000124450.07016.1D
Publication status	Published - 23 Mar 2004

Keywords

Allosteric Regulation
Animals
Anoxia
Aorta, Thoracic
Cardiac Output
Cell Hypoxia
Erythrocytes
Female
Heart Failure
Hemoglobins
Humans
In Vitro Techniques
Iron
Lung
Male
Middle Aged
Nitric Oxide
Nitrogen Oxides
Oxygen
Partial Pressure
Rabbits
S-Nitrosoglutathione
Vasodilation

Access to Document

10.1161/01.CIR.0000124450.07016.1D

Cite this

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title = "Red blood cell nitric oxide as an endocrine vasoregulator: A potential role in congestive heart failure",

abstract = "A respiratory cycle for nitric oxide (NO) would involve the formation of vasoactive metabolites between NO and hemoglobin during pulmonary oxygenation. We investigated the role of these metabolites in hypoxic tissue in vitro and in vivo in healthy subjects and patients with congestive heart failure (CHF).",

keywords = "Allosteric Regulation, Animals, Anoxia, Aorta, Thoracic, Cardiac Output, Cell Hypoxia, Erythrocytes, Female, Heart Failure, Hemoglobins, Humans, In Vitro Techniques, Iron, Lung, Male, Middle Aged, Nitric Oxide, Nitrogen Oxides, Oxygen, Partial Pressure, Rabbits, S-Nitrosoglutathione, Vasodilation",

author = "Borunendra Datta and Timothy Tufnell-Barrett and Bleasdale, {Robert A.} and Jones, {Christopher J. H.} and Ian Beeton and Vincent Paul and Michael Frenneaux and Philip James",

year = "2004",

month = mar,

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doi = "10.1161/01.CIR.0000124450.07016.1D",

language = "English",

volume = "109",

pages = "1339--1342",

journal = "Circulation",

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T1 - Red blood cell nitric oxide as an endocrine vasoregulator: A potential role in congestive heart failure

AU - Datta, Borunendra

AU - Tufnell-Barrett, Timothy

AU - Bleasdale, Robert A.

AU - Jones, Christopher J. H.

AU - Beeton, Ian

AU - Paul, Vincent

AU - Frenneaux, Michael

AU - James, Philip

PY - 2004/3/23

Y1 - 2004/3/23

N2 - A respiratory cycle for nitric oxide (NO) would involve the formation of vasoactive metabolites between NO and hemoglobin during pulmonary oxygenation. We investigated the role of these metabolites in hypoxic tissue in vitro and in vivo in healthy subjects and patients with congestive heart failure (CHF).

AB - A respiratory cycle for nitric oxide (NO) would involve the formation of vasoactive metabolites between NO and hemoglobin during pulmonary oxygenation. We investigated the role of these metabolites in hypoxic tissue in vitro and in vivo in healthy subjects and patients with congestive heart failure (CHF).

KW - Allosteric Regulation

KW - Animals

KW - Anoxia

KW - Aorta, Thoracic

KW - Cardiac Output

KW - Cell Hypoxia

KW - Erythrocytes

KW - Female

KW - Heart Failure

KW - Hemoglobins

KW - Humans

KW - In Vitro Techniques

KW - Iron

KW - Lung

KW - Male

KW - Middle Aged

KW - Nitric Oxide

KW - Nitrogen Oxides

KW - Oxygen

KW - Partial Pressure

KW - Rabbits

KW - S-Nitrosoglutathione

KW - Vasodilation

U2 - 10.1161/01.CIR.0000124450.07016.1D

DO - 10.1161/01.CIR.0000124450.07016.1D

M3 - Article

C2 - 15023874

VL - 109

SP - 1339

EP - 1342

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 11

ER -