Red blood cell nitric oxide as an endocrine vasoregulator: a potential role in congestive heart failure

Borunendra Datta, Timothy Tufnell-Barrett, Robert A Bleasdale, Christopher J H Jones, Ian Beeton, Vincent Paul, Michael Frenneaux, Philip James

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)


A respiratory cycle for nitric oxide (NO) would involve the formation of vasoactive metabolites between NO and hemoglobin during pulmonary oxygenation. We investigated the role of these metabolites in hypoxic tissue in vitro and in vivo in healthy subjects and patients with congestive heart failure (CHF).
Original languageEnglish
Pages (from-to)1339-1342
Number of pages4
Issue number11
Publication statusPublished - 23 Mar 2004


  • Allosteric Regulation
  • Animals
  • Anoxia
  • Aorta, Thoracic
  • Cardiac Output
  • Cell Hypoxia
  • Erythrocytes
  • Female
  • Heart Failure
  • Hemoglobins
  • Humans
  • In Vitro Techniques
  • Iron
  • Lung
  • Male
  • Middle Aged
  • Nitric Oxide
  • Nitrogen Oxides
  • Oxygen
  • Partial Pressure
  • Rabbits
  • S-Nitrosoglutathione
  • Vasodilation

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