Reduced beta-cell function in offspring of mothers with young-onset type 2 diabetes

R. Singh; E. Pearson; P. J. Avery; M. McCarthy; J. Levy; G. Hitman; M. J. Sampson; M. Walker; A. T. Hattersley

doi:10.1007/s00125-006-0285-5

Reduced beta-cell function in offspring of mothers with young-onset type 2 diabetes

R. Singh, E. Pearson, P. J. Avery, M. McCarthy, J. Levy, G. Hitman, M. J. Sampson, M. Walker, A. T. Hattersley

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Animal models indicate that even exposure to mild maternal hyperglycaemia in utero is detrimental to the beta cell function of the offspring, but evidence of this in humans is limited. In Europids who are diagnosed with type 2 diabetes before the age of 50 years, the risk of diabetes in the offspring of the diabetic mothers is greatly increased compared with the risk in those born to diabetic fathers. We hypothesised that offspring born to mothers with young-onset type 2 diabetes would have been exposed to mild hyperglycaemia in utero, so we studied the impact of this on their beta cell function.

Original language	English
Pages (from-to)	1876-1880
Number of pages	5
Journal	Diabetologia
Volume	49
Issue number	8
DOIs	https://doi.org/10.1007/s00125-006-0285-5
Publication status	Published - Aug 2006

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10.1007/s00125-006-0285-5

Cite this

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abstract = "Animal models indicate that even exposure to mild maternal hyperglycaemia in utero is detrimental to the beta cell function of the offspring, but evidence of this in humans is limited. In Europids who are diagnosed with type 2 diabetes before the age of 50 years, the risk of diabetes in the offspring of the diabetic mothers is greatly increased compared with the risk in those born to diabetic fathers. We hypothesised that offspring born to mothers with young-onset type 2 diabetes would have been exposed to mild hyperglycaemia in utero, so we studied the impact of this on their beta cell function.",

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AU - Pearson, E.

AU - Avery, P. J.

AU - McCarthy, M.

AU - Levy, J.

AU - Hitman, G.

AU - Sampson, M. J.

AU - Walker, M.

AU - Hattersley, A. T.

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N2 - Animal models indicate that even exposure to mild maternal hyperglycaemia in utero is detrimental to the beta cell function of the offspring, but evidence of this in humans is limited. In Europids who are diagnosed with type 2 diabetes before the age of 50 years, the risk of diabetes in the offspring of the diabetic mothers is greatly increased compared with the risk in those born to diabetic fathers. We hypothesised that offspring born to mothers with young-onset type 2 diabetes would have been exposed to mild hyperglycaemia in utero, so we studied the impact of this on their beta cell function.

AB - Animal models indicate that even exposure to mild maternal hyperglycaemia in utero is detrimental to the beta cell function of the offspring, but evidence of this in humans is limited. In Europids who are diagnosed with type 2 diabetes before the age of 50 years, the risk of diabetes in the offspring of the diabetic mothers is greatly increased compared with the risk in those born to diabetic fathers. We hypothesised that offspring born to mothers with young-onset type 2 diabetes would have been exposed to mild hyperglycaemia in utero, so we studied the impact of this on their beta cell function.

U2 - 10.1007/s00125-006-0285-5

DO - 10.1007/s00125-006-0285-5

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