Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

Mohammad Nassimizadeh; Houman Ashrafian; Nigel E Drury; Neil J Howell; Janet Digby; Domenico Pagano; Michael P Frenneaux; Gustav V R Born

doi:10.1177/1479164110376207

Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

Mohammad Nassimizadeh, Houman Ashrafian, Nigel E Drury, Neil J Howell, Janet Digby, Domenico Pagano, Michael P Frenneaux, Gustav V R Born

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.

Original language	English
Pages (from-to)	213-5
Number of pages	3
Journal	Diabetes & Vascular Disease Research
Volume	7
Issue number	3
DOIs	https://doi.org/10.1177/1479164110376207
Publication status	Published - Jul 2010

Keywords

Case-Control Studies
Diabetes Mellitus, Type 2
Diabetic Angiopathies
Endothelium, Vascular
Ferritins
Glycocalyx
Humans
Mammary Arteries
Microscopy, Electron
N-Acetylneuraminic Acid
Staining and Labeling
Surface Properties

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/1479164110376207

Cite this

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title = "Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients",

abstract = "Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.",

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AU - Nassimizadeh, Mohammad

AU - Ashrafian, Houman

AU - Drury, Nigel E

AU - Howell, Neil J

AU - Digby, Janet

AU - Pagano, Domenico

AU - Frenneaux, Michael P

AU - Born, Gustav V R

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KW - Diabetes Mellitus, Type 2

KW - Diabetic Angiopathies

KW - Endothelium, Vascular

KW - Ferritins

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KW - Humans

KW - Mammary Arteries

KW - Microscopy, Electron

KW - N-Acetylneuraminic Acid

KW - Staining and Labeling

KW - Surface Properties

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