Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

Mohammad Nassimizadeh, Houman Ashrafian, Nigel E Drury, Neil J Howell, Janet Digby, Domenico Pagano, Michael P Frenneaux, Gustav V R Born

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.
Original languageEnglish
Pages (from-to)213-5
Number of pages3
JournalDiabetes & Vascular Disease Research
Issue number3
Publication statusPublished - Jul 2010


  • Case-Control Studies
  • Diabetes Mellitus, Type 2
  • Diabetic Angiopathies
  • Endothelium, Vascular
  • Ferritins
  • Glycocalyx
  • Humans
  • Mammary Arteries
  • Microscopy, Electron
  • N-Acetylneuraminic Acid
  • Staining and Labeling
  • Surface Properties

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