Reduced white matter integrity in healthy individuals carrying the A-allele at DISC1 Ser704Cys

E. Sprooten; J. E. Sussmann; T. W. Moorhead; H. C. Whalley; C. Ffrench-Constant; H. P. Blumberg; M. E. Bastin; J. Hall; S. M. Lawrie; A. M. McIntosh

doi:10.1038/mp.2011.69

Reduced white matter integrity in healthy individuals carrying the A-allele at DISC1 Ser704Cys

E. Sprooten, J. E. Sussmann, T. W. Moorhead, H. C. Whalley, C. Ffrench-Constant, H. P. Blumberg, M. E. Bastin, J. Hall, S. M. Lawrie, A. M. McIntosh

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Association of fractional anisotropy (FA) with the DISC1 Ser704Cys allele in healthy individuals. Tract-based spatial statistics were applied, followed by voxel-wise comparisons using ‘randomise’ in FSL (http://www.fmrib.ox.ac.uk/fsl). Voxels with significantly higher FA in TT homozygotes compared with AA homozygotes are shown in red–yellow (PFWE<0.05). There were no voxels in which the AA group had significantly higher FA. The images are shown in radiological convention. For more info on this topic, please refer to the article by Sprooten et al. on pages 688–689.

Original language	English
Article number	685
Journal	Molecular Psychiatry
Volume	16
Issue number	7
Early online date	23 Jun 2011
DOIs	https://doi.org/10.1038/mp.2011.69
Publication status	Published - Jul 2011

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10.1038/mp.2011.69

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title = "Reduced white matter integrity in healthy individuals carrying the A-allele at DISC1 Ser704Cys",

abstract = "Association of fractional anisotropy (FA) with the DISC1 Ser704Cys allele in healthy individuals. Tract-based spatial statistics were applied, followed by voxel-wise comparisons using {\textquoteleft}randomise{\textquoteright} in FSL (http://www.fmrib.ox.ac.uk/fsl). Voxels with significantly higher FA in TT homozygotes compared with AA homozygotes are shown in red–yellow (PFWE<0.05). There were no voxels in which the AA group had significantly higher FA. The images are shown in radiological convention. For more info on this topic, please refer to the article by Sprooten et al. on pages 688–689.",

author = "E. Sprooten and Sussmann, {J. E.} and Moorhead, {T. W.} and Whalley, {H. C.} and C. Ffrench-Constant and Blumberg, {H. P.} and Bastin, {M. E.} and J. Hall and Lawrie, {S. M.} and McIntosh, {A. M.}",

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doi = "10.1038/mp.2011.69",

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AU - Sprooten, E.

AU - Sussmann, J. E.

AU - Moorhead, T. W.

AU - Whalley, H. C.

AU - Ffrench-Constant, C.

AU - Blumberg, H. P.

AU - Bastin, M. E.

AU - Hall, J.

AU - Lawrie, S. M.

AU - McIntosh, A. M.

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N2 - Association of fractional anisotropy (FA) with the DISC1 Ser704Cys allele in healthy individuals. Tract-based spatial statistics were applied, followed by voxel-wise comparisons using ‘randomise’ in FSL (http://www.fmrib.ox.ac.uk/fsl). Voxels with significantly higher FA in TT homozygotes compared with AA homozygotes are shown in red–yellow (PFWE<0.05). There were no voxels in which the AA group had significantly higher FA. The images are shown in radiological convention. For more info on this topic, please refer to the article by Sprooten et al. on pages 688–689.

AB - Association of fractional anisotropy (FA) with the DISC1 Ser704Cys allele in healthy individuals. Tract-based spatial statistics were applied, followed by voxel-wise comparisons using ‘randomise’ in FSL (http://www.fmrib.ox.ac.uk/fsl). Voxels with significantly higher FA in TT homozygotes compared with AA homozygotes are shown in red–yellow (PFWE<0.05). There were no voxels in which the AA group had significantly higher FA. The images are shown in radiological convention. For more info on this topic, please refer to the article by Sprooten et al. on pages 688–689.

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Reduced white matter integrity in healthy individuals carrying the A-allele at DISC1 Ser704Cys

Abstract

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