Regulation of jejunal glucose transporter expression by forskolin

Mark Williams; Paul Sharp

doi:10.1016/S0005-2736(01)00449-7

Regulation of jejunal glucose transporter expression by forskolin

Mark Williams, Paul Sharp

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

We have investigated the effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively. Forskolin treatment increased SGLT1 but decreased GLUT2 expression in mid and lower villus enterocytes. No change in transporter expression was noted in upper villus cells. Likewise, cyclic AMP levels were raised in mid and lower but not upper villus cells. The implications of these data for glucose transport are discussed.

Original language	English
Pages (from-to)	179-185
Number of pages	7
Journal	Biochimica et Biophysica Acta-Biomembranes
Volume	1559
Issue number	2
DOIs	https://doi.org/10.1016/S0005-2736(01)00449-7
Publication status	Published - 2002

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Cite this

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title = "Regulation of jejunal glucose transporter expression by forskolin",

abstract = "We have investigated the effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively. Forskolin treatment increased SGLT1 but decreased GLUT2 expression in mid and lower villus enterocytes. No change in transporter expression was noted in upper villus cells. Likewise, cyclic AMP levels were raised in mid and lower but not upper villus cells. The implications of these data for glucose transport are discussed.",

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AB - We have investigated the effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively. Forskolin treatment increased SGLT1 but decreased GLUT2 expression in mid and lower villus enterocytes. No change in transporter expression was noted in upper villus cells. Likewise, cyclic AMP levels were raised in mid and lower but not upper villus cells. The implications of these data for glucose transport are discussed.

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DO - 10.1016/S0005-2736(01)00449-7

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JO - Biochimica et Biophysica Acta-Biomembranes

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