Regulation of jejunal glucose transporter expression by forskolin

M. R. Williams, P. Sharp

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20 Citations (Scopus)

Abstract

We have investigated the effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively. Forskolin treatment increased SGLT1 but decreased GLUT2 expression in mid and lower villus enterocytes. No change in transporter expression was noted in upper villus cells. Likewise, cyclic AMP levels were raised in mid and lower but not upper villus cells. The implications of these data for glucose transport are discussed.
Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalBiochimica et Biophysica Acta (BBA) - Biomembranes
Volume1559
Issue number2
DOIs
Publication statusPublished - 2002

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