Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F

C Roger White, Lesley E Smythies, David K Crossman, Mayakonda N Palgunachari, G M Anantharamaiah, Geeta Datta

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The apolipoprotein A-I (apoA-I) mimetic peptide 4F favors the differentiation of human monocytes to an anti-inflammatory phenotype and attenuates lipopolysaccharide (LPS)-induced inflammatory responses. We investigated the effects of LPS on the Toll-like receptor (TLR) signaling pathway in 4F-differentiated monocyte-derived macrophages.
Original languageEnglish
Pages (from-to)2631-9
Number of pages9
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume32
Issue number11
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Active Transport, Cell Nucleus
  • Anti-Inflammatory Agents
  • Apolipoprotein A-I
  • Caveolin 1
  • Cells, Cultured
  • Cholesterol
  • Cytokines
  • Down-Regulation
  • Flow Cytometry
  • Gene Expression Profiling
  • Humans
  • Inflammation
  • Inflammation Mediators
  • Lipopolysaccharides
  • Macrophages
  • Membrane Microdomains
  • Oligonucleotide Array Sequence Analysis
  • Peptides
  • Phosphorylation
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction
  • Time Factors
  • Toll-Like Receptors
  • Transcription Factor RelA
  • Transcription, Genetic

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