Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F

C Roger White; Lesley E Smythies; David K Crossman; Mayakonda N Palgunachari; G M Anantharamaiah; Geeta Datta

doi:10.1161/ATVBAHA.112.300167

Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F

C Roger White, Lesley E Smythies, David K Crossman, Mayakonda N Palgunachari, G M Anantharamaiah, Geeta Datta

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

The apolipoprotein A-I (apoA-I) mimetic peptide 4F favors the differentiation of human monocytes to an anti-inflammatory phenotype and attenuates lipopolysaccharide (LPS)-induced inflammatory responses. We investigated the effects of LPS on the Toll-like receptor (TLR) signaling pathway in 4F-differentiated monocyte-derived macrophages.

Original language	English
Pages (from-to)	2631-9
Number of pages	9
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	32
Issue number	11
DOIs	https://doi.org/10.1161/ATVBAHA.112.300167
Publication status	Published - Nov 2012

Keywords

Active Transport, Cell Nucleus
Anti-Inflammatory Agents
Apolipoprotein A-I
Caveolin 1
Cells, Cultured
Cholesterol
Cytokines
Down-Regulation
Flow Cytometry
Gene Expression Profiling
Humans
Inflammation
Inflammation Mediators
Lipopolysaccharides
Macrophages
Membrane Microdomains
Oligonucleotide Array Sequence Analysis
Peptides
Phosphorylation
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Time Factors
Toll-Like Receptors
Transcription Factor RelA
Transcription, Genetic

Access to Document

10.1161/ATVBAHA.112.300167

Cite this

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title = "Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F",

abstract = "The apolipoprotein A-I (apoA-I) mimetic peptide 4F favors the differentiation of human monocytes to an anti-inflammatory phenotype and attenuates lipopolysaccharide (LPS)-induced inflammatory responses. We investigated the effects of LPS on the Toll-like receptor (TLR) signaling pathway in 4F-differentiated monocyte-derived macrophages.",

keywords = "Active Transport, Cell Nucleus, Anti-Inflammatory Agents, Apolipoprotein A-I, Caveolin 1, Cells, Cultured, Cholesterol, Cytokines, Down-Regulation, Flow Cytometry, Gene Expression Profiling, Humans, Inflammation, Inflammation Mediators, Lipopolysaccharides, Macrophages, Membrane Microdomains, Oligonucleotide Array Sequence Analysis, Peptides, Phosphorylation, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Time Factors, Toll-Like Receptors, Transcription Factor RelA, Transcription, Genetic",

author = "White, {C Roger} and Smythies, {Lesley E} and Crossman, {David K} and Palgunachari, {Mayakonda N} and Anantharamaiah, {G M} and Geeta Datta",

year = "2012",

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doi = "10.1161/ATVBAHA.112.300167",

language = "English",

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AU - White, C Roger

AU - Smythies, Lesley E

AU - Crossman, David K

AU - Palgunachari, Mayakonda N

AU - Anantharamaiah, G M

AU - Datta, Geeta

PY - 2012/11

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KW - Active Transport, Cell Nucleus

KW - Anti-Inflammatory Agents

KW - Apolipoprotein A-I

KW - Caveolin 1

KW - Cells, Cultured

KW - Cholesterol

KW - Cytokines

KW - Down-Regulation

KW - Flow Cytometry

KW - Gene Expression Profiling

KW - Humans

KW - Inflammation

KW - Inflammation Mediators

KW - Lipopolysaccharides

KW - Macrophages

KW - Membrane Microdomains

KW - Oligonucleotide Array Sequence Analysis

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KW - Phosphorylation

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Signal Transduction

KW - Time Factors

KW - Toll-Like Receptors

KW - Transcription Factor RelA

KW - Transcription, Genetic

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DO - 10.1161/ATVBAHA.112.300167

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JO - Arteriosclerosis, Thrombosis, and Vascular Biology

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