Regulation of the neural stem cell compartment by extracellular matrix constituents

Ursula Theocharidis, Katherine Long, Charles ffrench-Constant, Andreas Faissner

Research output: Chapter in Book/Report/Conference proceedingChapter

44 Citations (Scopus)

Abstract

Neural stem cells (NSCs) derive from the neuroepithelium of the neural tube, develop into radial glial cells, and recede at later developmental stages. In the adult, late descendants of these embryonic NSCs reside in discretely confined areas of the central nervous system, the stem cell niches. The best accepted canonical niches are the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus of the hippocampus. Stem cell niches provide a privileged environment to NSCs that supports self-renewal and maintenance of this cellular compartment. While numerous studies have highlighted the importance of transcription factors, morphogens, cytokines, and growth factors as intrinsic and extrinsic factors of stem cell regulation, less attention has been paid to the molecular micromilieu that characterizes the stem cell niches. In this chapter, we summarize increasing evidence that the extracellular matrix (ECM) of the stem cell environment is of crucial importance for the biology of this cellular compartment. A deeper understanding of the molecular composition of the ECM, the complementary receptors, and the signal transduction pathways engaged may prove highly relevant for harnessing NSCs in the context of biotechnological applications.

Original languageEnglish
Title of host publicationProgress in Brain Research
PublisherElsevier
Pages3-28
Number of pages26
DOIs
Publication statusPublished - 2014

Publication series

NameProgress in Brain Research
Volume214
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Keywords

  • Asymmetrical division
  • Extracellular matrix
  • Glial progenitors
  • Integrins
  • Laminin
  • Neural stem cell niche
  • Phosphacan
  • Proteoglycans
  • Radial glial cells
  • Subventricular zone
  • Tenascin

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