Relationship between brain structure and antisaccadic eye movements in healthy humans

Ulrich Ettinger; Veena Kumari; Xavier A. Chitnis; Philip J. Corr; Alex L. Sumich; Sophia Rabe-Hesketh; Trevor J. Crawford; Tonmoy Sharma

doi:10.1016/S0304-3940(02)00517-7

Relationship between brain structure and antisaccadic eye movements in healthy humans

Ulrich Ettinger, Veena Kumari, Xavier A. Chitnis, Philip J. Corr, Alex L. Sumich, Sophia Rabe-Hesketh, Trevor J. Crawford, Tonmoy Sharma

School of Psychology

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

This study used structural magnetic resonance imaging (MRI) to investigate associations between brain structure and saccadic eye movements. Seventeen healthy subjects underwent structural MRI and infra-red oculographic assessment of a reflexive saccade task. Volumes of prefrontal, premotor, and occipitoparietal cortex, caudate, thalamus, and cerebellar vermis were used as predictors in multiple regression with prosaccade gain as a dependent variable, controlling for whole-brain volume. Using voxel-based morphometry (VBM), gain was entered into correlational analysis with grey matter density. Regression analysis indicated that vermis volumes predicted prosaccade gain. VBM replicated this finding: gain was correlated with grey matter in the left cerebellar hemisphere and vermis. These findings agree with previous studies on the role of the cerebellar vermis in saccadic gain and support the validity of structural neuroimaging methods in elucidating the neural correlates of saccadic eye movements.

Original language	English
Pages (from-to)	225-228
Number of pages	4
Journal	Neuroscience Letters
Volume	328
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(02)00517-7
Publication status	Published - 16 Aug 2002

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10.1016/S0304-3940(02)00517-7

Cite this

@article{66b4baf754284dbfbba27ec9517d2161,

title = "Relationship between brain structure and antisaccadic eye movements in healthy humans",

abstract = "This study used structural magnetic resonance imaging (MRI) to investigate associations between brain structure and saccadic eye movements. Seventeen healthy subjects underwent structural MRI and infra-red oculographic assessment of a reflexive saccade task. Volumes of prefrontal, premotor, and occipitoparietal cortex, caudate, thalamus, and cerebellar vermis were used as predictors in multiple regression with prosaccade gain as a dependent variable, controlling for whole-brain volume. Using voxel-based morphometry (VBM), gain was entered into correlational analysis with grey matter density. Regression analysis indicated that vermis volumes predicted prosaccade gain. VBM replicated this finding: gain was correlated with grey matter in the left cerebellar hemisphere and vermis. These findings agree with previous studies on the role of the cerebellar vermis in saccadic gain and support the validity of structural neuroimaging methods in elucidating the neural correlates of saccadic eye movements.",

author = "Ulrich Ettinger and Veena Kumari and Chitnis, {Xavier A.} and Corr, {Philip J.} and Sumich, {Alex L.} and Sophia Rabe-Hesketh and Crawford, {Trevor J.} and Tonmoy Sharma",

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T1 - Relationship between brain structure and antisaccadic eye movements in healthy humans

AU - Ettinger, Ulrich

AU - Kumari, Veena

AU - Chitnis, Xavier A.

AU - Corr, Philip J.

AU - Sumich, Alex L.

AU - Rabe-Hesketh, Sophia

AU - Crawford, Trevor J.

AU - Sharma, Tonmoy

PY - 2002/8/16

Y1 - 2002/8/16

N2 - This study used structural magnetic resonance imaging (MRI) to investigate associations between brain structure and saccadic eye movements. Seventeen healthy subjects underwent structural MRI and infra-red oculographic assessment of a reflexive saccade task. Volumes of prefrontal, premotor, and occipitoparietal cortex, caudate, thalamus, and cerebellar vermis were used as predictors in multiple regression with prosaccade gain as a dependent variable, controlling for whole-brain volume. Using voxel-based morphometry (VBM), gain was entered into correlational analysis with grey matter density. Regression analysis indicated that vermis volumes predicted prosaccade gain. VBM replicated this finding: gain was correlated with grey matter in the left cerebellar hemisphere and vermis. These findings agree with previous studies on the role of the cerebellar vermis in saccadic gain and support the validity of structural neuroimaging methods in elucidating the neural correlates of saccadic eye movements.

AB - This study used structural magnetic resonance imaging (MRI) to investigate associations between brain structure and saccadic eye movements. Seventeen healthy subjects underwent structural MRI and infra-red oculographic assessment of a reflexive saccade task. Volumes of prefrontal, premotor, and occipitoparietal cortex, caudate, thalamus, and cerebellar vermis were used as predictors in multiple regression with prosaccade gain as a dependent variable, controlling for whole-brain volume. Using voxel-based morphometry (VBM), gain was entered into correlational analysis with grey matter density. Regression analysis indicated that vermis volumes predicted prosaccade gain. VBM replicated this finding: gain was correlated with grey matter in the left cerebellar hemisphere and vermis. These findings agree with previous studies on the role of the cerebellar vermis in saccadic gain and support the validity of structural neuroimaging methods in elucidating the neural correlates of saccadic eye movements.

U2 - 10.1016/S0304-3940(02)00517-7

DO - 10.1016/S0304-3940(02)00517-7

M3 - Article

VL - 328

SP - 225

EP - 228

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

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ER -