Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease

S C Ng, J L Benjamin, N E McCarthy, C R H Hedin, A Koutsoumpas, S Plamondon, C L Price, A L Hart, M A Kamm, A Forbes, S C Knight, J O Lindsay, K Whelan, A J Stagg

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Abstract

Altered intestinal dendritic cell (DC) function underlies dysregulated T-cell responses to bacteria in Crohn's disease (CD) but it is unclear whether composition of the intestinal microbiota impacts local DC function. We assessed the relationship between DC function with disease activity and intestinal microbiota in patients with CD.
Original languageEnglish
Pages (from-to)2027-2037
Number of pages11
JournalInflammatory Bowel Diseases
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Adult
  • Aged
  • Antigens, CD40
  • C-Reactive Protein
  • Case-Control Studies
  • Crohn Disease
  • Dendritic Cells
  • Female
  • Flow Cytometry
  • Gastrointestinal Tract
  • Humans
  • In Situ Hybridization, Fluorescence
  • Interleukin-10
  • Interleukin-6
  • Intestinal Mucosa
  • Male
  • Metagenome
  • Middle Aged
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Young Adult

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