Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease

S C Ng; J L Benjamin; N E McCarthy; C R H Hedin; A Koutsoumpas; S Plamondon; C L Price; A L Hart; M A Kamm; A Forbes; S C Knight; J O Lindsay; K Whelan; A J Stagg

doi:10.1002/ibd.21590

Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease

S C Ng, J L Benjamin, N E McCarthy, C R H Hedin, A Koutsoumpas, S Plamondon, C L Price, A L Hart, M A Kamm, A Forbes, S C Knight, J O Lindsay, K Whelan, A J Stagg

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

Altered intestinal dendritic cell (DC) function underlies dysregulated T-cell responses to bacteria in Crohn's disease (CD) but it is unclear whether composition of the intestinal microbiota impacts local DC function. We assessed the relationship between DC function with disease activity and intestinal microbiota in patients with CD.

Original language	English
Pages (from-to)	2027-2037
Number of pages	11
Journal	Inflammatory Bowel Diseases
Volume	17
Issue number	10
DOIs	https://doi.org/10.1002/ibd.21590
Publication status	Published - Oct 2011

Keywords

Adult
Aged
Antigens, CD40
C-Reactive Protein
Case-Control Studies
Crohn Disease
Dendritic Cells
Female
Flow Cytometry
Gastrointestinal Tract
Humans
In Situ Hybridization, Fluorescence
Interleukin-10
Interleukin-6
Intestinal Mucosa
Male
Metagenome
Middle Aged
Toll-Like Receptor 2
Toll-Like Receptor 4
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/ibd.21590

Cite this

Ng, S. C., Benjamin, J. L., McCarthy, N. E., Hedin, C. R. H., Koutsoumpas, A., Plamondon, S., Price, C. L., Hart, A. L., Kamm, M. A., Forbes, A., Knight, S. C., Lindsay, J. O., Whelan, K., & Stagg, A. J. (2011). Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease. Inflammatory Bowel Diseases, 17(10), 2027-2037. https://doi.org/10.1002/ibd.21590

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title = "Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease",

abstract = "Altered intestinal dendritic cell (DC) function underlies dysregulated T-cell responses to bacteria in Crohn's disease (CD) but it is unclear whether composition of the intestinal microbiota impacts local DC function. We assessed the relationship between DC function with disease activity and intestinal microbiota in patients with CD.",

keywords = "Adult, Aged, Antigens, CD40, C-Reactive Protein, Case-Control Studies, Crohn Disease, Dendritic Cells, Female, Flow Cytometry, Gastrointestinal Tract, Humans, In Situ Hybridization, Fluorescence, Interleukin-10, Interleukin-6, Intestinal Mucosa, Male, Metagenome, Middle Aged, Toll-Like Receptor 2, Toll-Like Receptor 4, Young Adult",

author = "Ng, {S C} and Benjamin, {J L} and McCarthy, {N E} and Hedin, {C R H} and A Koutsoumpas and S Plamondon and Price, {C L} and Hart, {A L} and Kamm, {M A} and A Forbes and Knight, {S C} and Lindsay, {J O} and K Whelan and Stagg, {A J}",

note = "Copyright {\textcopyright} 2010 Crohn's & Colitis Foundation of America, Inc.",

year = "2011",

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language = "English",

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issn = "1078-0998",

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Ng, SC, Benjamin, JL, McCarthy, NE, Hedin, CRH, Koutsoumpas, A, Plamondon, S, Price, CL, Hart, AL, Kamm, MA, Forbes, A, Knight, SC, Lindsay, JO, Whelan, K & Stagg, AJ 2011, 'Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease', Inflammatory Bowel Diseases, vol. 17, no. 10, pp. 2027-2037. https://doi.org/10.1002/ibd.21590

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T1 - Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease

AU - Ng, S C

AU - Benjamin, J L

AU - McCarthy, N E

AU - Hedin, C R H

AU - Koutsoumpas, A

AU - Plamondon, S

AU - Price, C L

AU - Hart, A L

AU - Kamm, M A

AU - Forbes, A

AU - Knight, S C

AU - Lindsay, J O

AU - Whelan, K

AU - Stagg, A J

PY - 2011/10

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N2 - Altered intestinal dendritic cell (DC) function underlies dysregulated T-cell responses to bacteria in Crohn's disease (CD) but it is unclear whether composition of the intestinal microbiota impacts local DC function. We assessed the relationship between DC function with disease activity and intestinal microbiota in patients with CD.

AB - Altered intestinal dendritic cell (DC) function underlies dysregulated T-cell responses to bacteria in Crohn's disease (CD) but it is unclear whether composition of the intestinal microbiota impacts local DC function. We assessed the relationship between DC function with disease activity and intestinal microbiota in patients with CD.

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KW - Aged

KW - Antigens, CD40

KW - C-Reactive Protein

KW - Case-Control Studies

KW - Crohn Disease

KW - Dendritic Cells

KW - Female

KW - Flow Cytometry

KW - Gastrointestinal Tract

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Interleukin-10

KW - Interleukin-6

KW - Intestinal Mucosa

KW - Male

KW - Metagenome

KW - Middle Aged

KW - Toll-Like Receptor 2

KW - Toll-Like Receptor 4

KW - Young Adult

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DO - 10.1002/ibd.21590

M3 - Article

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VL - 17

SP - 2027

EP - 2037

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

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