Relationship between plasma, atrial and ventricular perhexiline concentrations in humans: insights into factors affecting myocardial uptake

Nigel E Drury; Giovanni Licari; Cher-Rin Chong; Neil J Howell; Michael P Frenneaux; John D Horowitz; Domenico Pagano; Benedetta C Sallustio

doi:10.1111/bcp.12254

Relationship between plasma, atrial and ventricular perhexiline concentrations in humans: insights into factors affecting myocardial uptake

Nigel E Drury, Giovanni Licari, Cher-Rin Chong, Neil J Howell, Michael P Frenneaux, John D Horowitz, Domenico Pagano, Benedetta C Sallustio

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Little is known regarding the steady-state uptake of drugs into the human myocardium. Perhexiline is a prophylactic anti-anginal drug which is increasingly also used in the treatment of heart failure and hypertrophic cardiomyopathy. We explored the relationship between plasma perhexiline concentrations and its uptake into the myocardium.

Original language	English
Pages (from-to)	789-95
Number of pages	7
Journal	British Journal of Clinical Pharmacology
Volume	77
Issue number	5
DOIs	https://doi.org/10.1111/bcp.12254
Publication status	Published - May 2014

Keywords

Age Factors
Aged
Biopsy
Double-Blind Method
Humans
Middle Aged
Myocardium
Perhexiline
Prospective Studies

Access to Document

10.1111/bcp.12254

Cite this

Drury, Nigel E ; Licari, Giovanni ; Chong, Cher-Rin ; Howell, Neil J ; Frenneaux, Michael P ; Horowitz, John D ; Pagano, Domenico ; Sallustio, Benedetta C. / Relationship between plasma, atrial and ventricular perhexiline concentrations in humans : insights into factors affecting myocardial uptake. In: British Journal of Clinical Pharmacology. 2014 ; Vol. 77, No. 5. pp. 789-95.

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abstract = "Little is known regarding the steady-state uptake of drugs into the human myocardium. Perhexiline is a prophylactic anti-anginal drug which is increasingly also used in the treatment of heart failure and hypertrophic cardiomyopathy. We explored the relationship between plasma perhexiline concentrations and its uptake into the myocardium.",

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Relationship between plasma, atrial and ventricular perhexiline concentrations in humans : insights into factors affecting myocardial uptake. / Drury, Nigel E; Licari, Giovanni; Chong, Cher-Rin; Howell, Neil J; Frenneaux, Michael P; Horowitz, John D; Pagano, Domenico; Sallustio, Benedetta C.

In: British Journal of Clinical Pharmacology, Vol. 77, No. 5, 05.2014, p. 789-95.

Research output: Contribution to journal › Article › peer-review

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KW - Biopsy

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KW - Middle Aged

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