Relationship between plasma, atrial and ventricular perhexiline concentrations in humans: insights into factors affecting myocardial uptake

Nigel E Drury, Giovanni Licari, Cher-Rin Chong, Neil J Howell, Michael P Frenneaux, John D Horowitz, Domenico Pagano, Benedetta C Sallustio

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Little is known regarding the steady-state uptake of drugs into the human myocardium. Perhexiline is a prophylactic anti-anginal drug which is increasingly also used in the treatment of heart failure and hypertrophic cardiomyopathy. We explored the relationship between plasma perhexiline concentrations and its uptake into the myocardium.
Original languageEnglish
Pages (from-to)789-95
Number of pages7
JournalBritish Journal of Clinical Pharmacology
Volume77
Issue number5
DOIs
Publication statusPublished - May 2014

Keywords

  • Age Factors
  • Aged
  • Biopsy
  • Double-Blind Method
  • Humans
  • Middle Aged
  • Myocardium
  • Perhexiline
  • Prospective Studies

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