Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs

Gyorgy Andreka, Marton Vertesaljai, Gergely Szantho, Gusztav Font, Zsolt Piroth, Geza Fontos, Eszter D Juhasz, Laszlo Szekely, Zsolt Szelid, Mark S Turner, Houman Ashrafian, Michael P Frenneaux, Peter Andreka

Research output: Contribution to journalArticlepeer-review

166 Citations (Scopus)

Abstract

Ischaemic preconditioning results in a reduction in ischaemic-reperfusion injury to the heart. This beneficial effect is seen both with direct local preconditioning of the myocardium and with remote preconditioning of easily accessible distant non-vital limb tissue. Ischaemic postconditioning with a comparable sequence of brief periods of local ischaemia, when applied immediately after the ischaemic insult, confers benefits similar to preconditioning.
Original languageEnglish
Pages (from-to)749-52
Number of pages4
JournalHeart
Volume93
Issue number6
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Angioplasty, Balloon, Coronary
  • Animals
  • Area Under Curve
  • Creatine Kinase
  • Female
  • Ischemic Preconditioning, Myocardial
  • Male
  • Myocardial Infarction
  • Myocardium
  • Sus scrofa

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