Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs

Gyorgy Andreka; Marton Vertesaljai; Gergely Szantho; Gusztav Font; Zsolt Piroth; Geza Fontos; Eszter D Juhasz; Laszlo Szekely; Zsolt Szelid; Mark S Turner; Houman Ashrafian; Michael P Frenneaux; Peter Andreka

doi:10.1136/hrt.2006.114504

Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs

Gyorgy Andreka, Marton Vertesaljai, Gergely Szantho, Gusztav Font, Zsolt Piroth, Geza Fontos, Eszter D Juhasz, Laszlo Szekely, Zsolt Szelid, Mark S Turner, Houman Ashrafian, Michael P Frenneaux, Peter Andreka

Research output: Contribution to journal › Article › peer-review

186 Citations (Scopus)

Abstract

Ischaemic preconditioning results in a reduction in ischaemic-reperfusion injury to the heart. This beneficial effect is seen both with direct local preconditioning of the myocardium and with remote preconditioning of easily accessible distant non-vital limb tissue. Ischaemic postconditioning with a comparable sequence of brief periods of local ischaemia, when applied immediately after the ischaemic insult, confers benefits similar to preconditioning.

Original language	English
Pages (from-to)	749-52
Number of pages	4
Journal	Heart
Volume	93
Issue number	6
DOIs	https://doi.org/10.1136/hrt.2006.114504
Publication status	Published - Jun 2007

Keywords

Angioplasty, Balloon, Coronary
Animals
Area Under Curve
Creatine Kinase
Female
Ischemic Preconditioning, Myocardial
Male
Myocardial Infarction
Myocardium
Sus scrofa

Access to Document

10.1136/hrt.2006.114504

Cite this

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title = "Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs",

abstract = "Ischaemic preconditioning results in a reduction in ischaemic-reperfusion injury to the heart. This beneficial effect is seen both with direct local preconditioning of the myocardium and with remote preconditioning of easily accessible distant non-vital limb tissue. Ischaemic postconditioning with a comparable sequence of brief periods of local ischaemia, when applied immediately after the ischaemic insult, confers benefits similar to preconditioning.",

keywords = "Angioplasty, Balloon, Coronary, Animals, Area Under Curve, Creatine Kinase, Female, Ischemic Preconditioning, Myocardial, Male, Myocardial Infarction, Myocardium, Sus scrofa",

author = "Gyorgy Andreka and Marton Vertesaljai and Gergely Szantho and Gusztav Font and Zsolt Piroth and Geza Fontos and Juhasz, {Eszter D} and Laszlo Szekely and Zsolt Szelid and Turner, {Mark S} and Houman Ashrafian and Frenneaux, {Michael P} and Peter Andreka",

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doi = "10.1136/hrt.2006.114504",

language = "English",

volume = "93",

pages = "749--52",

journal = "Heart",

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T1 - Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs

AU - Andreka, Gyorgy

AU - Vertesaljai, Marton

AU - Szantho, Gergely

AU - Font, Gusztav

AU - Piroth, Zsolt

AU - Fontos, Geza

AU - Juhasz, Eszter D

AU - Szekely, Laszlo

AU - Szelid, Zsolt

AU - Turner, Mark S

AU - Ashrafian, Houman

AU - Frenneaux, Michael P

AU - Andreka, Peter

PY - 2007/6

Y1 - 2007/6

N2 - Ischaemic preconditioning results in a reduction in ischaemic-reperfusion injury to the heart. This beneficial effect is seen both with direct local preconditioning of the myocardium and with remote preconditioning of easily accessible distant non-vital limb tissue. Ischaemic postconditioning with a comparable sequence of brief periods of local ischaemia, when applied immediately after the ischaemic insult, confers benefits similar to preconditioning.

AB - Ischaemic preconditioning results in a reduction in ischaemic-reperfusion injury to the heart. This beneficial effect is seen both with direct local preconditioning of the myocardium and with remote preconditioning of easily accessible distant non-vital limb tissue. Ischaemic postconditioning with a comparable sequence of brief periods of local ischaemia, when applied immediately after the ischaemic insult, confers benefits similar to preconditioning.

KW - Angioplasty, Balloon, Coronary

KW - Animals

KW - Area Under Curve

KW - Creatine Kinase

KW - Female

KW - Ischemic Preconditioning, Myocardial

KW - Male

KW - Myocardial Infarction

KW - Myocardium

KW - Sus scrofa

U2 - 10.1136/hrt.2006.114504

DO - 10.1136/hrt.2006.114504

M3 - Article

C2 - 17449499

SN - 1355-6037

VL - 93

SP - 749

EP - 752

JO - Heart

JF - Heart

IS - 6

ER -