Replication licensing and cancer: a fatal entanglement?

J. Julian Blow, Peter J. Gillespie

Research output: Contribution to journalComment/debatepeer-review


Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under-or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.
Original languageEnglish
Pages (from-to)799-806
Number of pages8
JournalNature Reviews Cancer
Issue number10
Publication statusPublished - 29 Aug 2008


  • Animals
  • Cell Cycle Proteins
  • Cell Transformation
  • Neoplastic
  • DNA Damage
  • DNA Replication
  • Humans
  • Mice
  • Neoplasms
  • Nuclear Proteins

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