Resistance in cancer: A target for drug discovery

M Searcey, LH Patterson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Resistance remains a major problem in the clinical utility of cancer chemotherapy. However, it also represents a tumour cell phenotype that is in many ways different, and thus distinguishable, from the majority of normal cells. Two approaches to the targeting of resistant cells are described involving intratumoral P450 expression, mechanisms of drug-efflux and defective DNA repair. It is suggested that the view of the solid tumour as a complex organ rather than a collection of individual cells will inform future drug development and both overcome and target multiple resistance mechanisms.
Original languageEnglish
Pages (from-to)457-460
Number of pages4
JournalCurrent Medicinal Chemistry - Anti-Cancer Agents
Volume4
Issue number5
Publication statusPublished - 2004

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