Resistance to natural and synthetic gene drive systems

Tom A. R. Price; Nikolai Windbichler; Robert L. Unckless; Andreas Sutter; Jan Niklas Runge; Perran A. Ross; Andrew Pomiankowski; Nicole L. Nuckolls; Catherine Montchamp-Moreau; Nicole Mideo; Oliver Y. Martin; Andri Manser; Mathieu Legros; Amanda M. Larracuente; Luke Holman; John Godwin; Neil Gemmell; Cécile Courret; Anna Buchman; Luke G. Barrett; Anna K. Lindholm

doi:10.1111/jeb.13693

Resistance to natural and synthetic gene drive systems

Tom A. R. Price, Nikolai Windbichler, Robert L. Unckless, Andreas Sutter, Jan Niklas Runge, Perran A. Ross, Andrew Pomiankowski, Nicole L. Nuckolls, Catherine Montchamp-Moreau, Nicole Mideo, Oliver Y. Martin, Andri Manser, Mathieu Legros, Amanda M. Larracuente, Luke Holman, John Godwin, Neil Gemmell, Cécile Courret, Anna Buchman, Luke G. BarrettAnna K. Lindholm

School of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

35 Citations (Scopus)

14 Downloads (Pure)

Abstract

Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.

Original language	English
Pages (from-to)	1345-1360
Number of pages	16
Journal	Journal of Evolutionary Biology
Volume	33
Issue number	10
Early online date	24 Sep 2020
DOIs	https://doi.org/10.1111/jeb.13693
Publication status	Published - 1 Oct 2020

Keywords

CRISPR-Cas9
fitness costs
meiotic drive
population suppression
selfish genetic elements
sex ratio distorter
transposable element
Wolbachia

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Price, T. A. R., Windbichler, N., Unckless, R. L., Sutter, A., Runge, J. N., Ross, P. A., Pomiankowski, A., Nuckolls, N. L., Montchamp-Moreau, C., Mideo, N., Martin, O. Y., Manser, A., Legros, M., Larracuente, A. M., Holman, L., Godwin, J., Gemmell, N., Courret, C., Buchman, A., ... Lindholm, A. K. (2020). Resistance to natural and synthetic gene drive systems. Journal of Evolutionary Biology, 33(10), 1345-1360. https://doi.org/10.1111/jeb.13693

Price, Tom A. R. ; Windbichler, Nikolai ; Unckless, Robert L. ; Sutter, Andreas ; Runge, Jan Niklas ; Ross, Perran A. ; Pomiankowski, Andrew ; Nuckolls, Nicole L. ; Montchamp-Moreau, Catherine ; Mideo, Nicole ; Martin, Oliver Y. ; Manser, Andri ; Legros, Mathieu ; Larracuente, Amanda M. ; Holman, Luke ; Godwin, John ; Gemmell, Neil ; Courret, Cécile ; Buchman, Anna ; Barrett, Luke G. ; Lindholm, Anna K. / Resistance to natural and synthetic gene drive systems. In: Journal of Evolutionary Biology. 2020 ; Vol. 33, No. 10. pp. 1345-1360.

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title = "Resistance to natural and synthetic gene drive systems",

abstract = "Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.",

keywords = "CRISPR-Cas9, fitness costs, meiotic drive, population suppression, selfish genetic elements, sex ratio distorter, transposable element, Wolbachia",

author = "Price, {Tom A. R.} and Nikolai Windbichler and Unckless, {Robert L.} and Andreas Sutter and Runge, {Jan Niklas} and Ross, {Perran A.} and Andrew Pomiankowski and Nuckolls, {Nicole L.} and Catherine Montchamp-Moreau and Nicole Mideo and Martin, {Oliver Y.} and Andri Manser and Mathieu Legros and Larracuente, {Amanda M.} and Luke Holman and John Godwin and Neil Gemmell and C{\'e}cile Courret and Anna Buchman and Barrett, {Luke G.} and Lindholm, {Anna K.}",

year = "2020",

month = oct,

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doi = "10.1111/jeb.13693",

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Price, TAR, Windbichler, N, Unckless, RL, Sutter, A, Runge, JN, Ross, PA, Pomiankowski, A, Nuckolls, NL, Montchamp-Moreau, C, Mideo, N, Martin, OY, Manser, A, Legros, M, Larracuente, AM, Holman, L, Godwin, J, Gemmell, N, Courret, C, Buchman, A, Barrett, LG & Lindholm, AK 2020, 'Resistance to natural and synthetic gene drive systems', Journal of Evolutionary Biology, vol. 33, no. 10, pp. 1345-1360. https://doi.org/10.1111/jeb.13693

Resistance to natural and synthetic gene drive systems. / Price, Tom A. R.; Windbichler, Nikolai; Unckless, Robert L.; Sutter, Andreas; Runge, Jan Niklas; Ross, Perran A.; Pomiankowski, Andrew; Nuckolls, Nicole L.; Montchamp-Moreau, Catherine; Mideo, Nicole; Martin, Oliver Y.; Manser, Andri; Legros, Mathieu; Larracuente, Amanda M.; Holman, Luke; Godwin, John; Gemmell, Neil; Courret, Cécile; Buchman, Anna; Barrett, Luke G.; Lindholm, Anna K.

In: Journal of Evolutionary Biology, Vol. 33, No. 10, 01.10.2020, p. 1345-1360.

Research output: Contribution to journal › Review article › peer-review

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T1 - Resistance to natural and synthetic gene drive systems

AU - Price, Tom A. R.

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AU - Unckless, Robert L.

AU - Sutter, Andreas

AU - Runge, Jan Niklas

AU - Ross, Perran A.

AU - Pomiankowski, Andrew

AU - Nuckolls, Nicole L.

AU - Montchamp-Moreau, Catherine

AU - Mideo, Nicole

AU - Martin, Oliver Y.

AU - Manser, Andri

AU - Legros, Mathieu

AU - Larracuente, Amanda M.

AU - Holman, Luke

AU - Godwin, John

AU - Gemmell, Neil

AU - Courret, Cécile

AU - Buchman, Anna

AU - Barrett, Luke G.

AU - Lindholm, Anna K.

PY - 2020/10/1

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N2 - Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.

AB - Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.

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KW - meiotic drive

KW - population suppression

KW - selfish genetic elements

KW - sex ratio distorter

KW - transposable element

KW - Wolbachia

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DO - 10.1111/jeb.13693

M3 - Review article

AN - SCOPUS:85091372396

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SP - 1345

EP - 1360

JO - Journal of Evolutionary Biology

JF - Journal of Evolutionary Biology

SN - 1010-061X

IS - 10

ER -

Resistance to natural and synthetic gene drive systems

Abstract

Keywords

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