TY - JOUR
T1 - Resisting death by metal
T2 - metabolism and Cu/Zn homeostasis in bacteria
AU - Sullivan, Matthew J.
AU - Terán, Ignacio
AU - Goh, Kelvin G.K.
AU - Ulett, Glen C.
N1 - Funding Information:
This work was supported by the National Health and Medical Research Council (Australia) grant to G.C.U., M.J. S. and K.G.K.G. [APP2021475], a Royal Society Research Grant to M.J.S. [RGS\R1\231151] and Medical Research Council (U.K.) funding for a Microbes, Microbiomes and Bioinformatics Doctoral Training Partnership (MMB-DTP) PhD scholarship to I.T.
Publisher Copyright:
© 2024 The Author(s).
PY - 2024/2/16
Y1 - 2024/2/16
N2 - Metal ions such as zinc and copper play important roles in host-microbe interactions and their availability can drastically affect the survival of pathogenic bacteria in a host niche. Mechanisms of metal homeostasis protect bacteria from starvation, or intoxication, defined as when metals are limiting, or in excess, respectively. In this mini-review, we summarise current knowledge on the mechanisms of resistance to metal stress in bacteria, focussing specifically on the homeostasis of cellular copper and zinc. This includes a summary of the factors that subvert metal stress in bacteria, which are independent of metal efflux systems, and commentary on the role of small molecules and metabolic systems as important mediators of metal resistance.
AB - Metal ions such as zinc and copper play important roles in host-microbe interactions and their availability can drastically affect the survival of pathogenic bacteria in a host niche. Mechanisms of metal homeostasis protect bacteria from starvation, or intoxication, defined as when metals are limiting, or in excess, respectively. In this mini-review, we summarise current knowledge on the mechanisms of resistance to metal stress in bacteria, focussing specifically on the homeostasis of cellular copper and zinc. This includes a summary of the factors that subvert metal stress in bacteria, which are independent of metal efflux systems, and commentary on the role of small molecules and metabolic systems as important mediators of metal resistance.
UR - http://www.scopus.com/inward/record.url?scp=85185713620&partnerID=8YFLogxK
U2 - 10.1042/ETLS20230115
DO - 10.1042/ETLS20230115
M3 - Review article
C2 - 38362914
AN - SCOPUS:85185713620
VL - 8
SP - 45
EP - 56
JO - Emerging Topics in Life Sciences
JF - Emerging Topics in Life Sciences
SN - 2397-8554
IS - 1
ER -