Resting functional connectivity reveals residual functional activity in Alzheimer's disease

Giovanna Zamboni, Gordon K. Wilcock, Gwenaelle Douaud, Erin Drazich, Ellen McCulloch, Nicola Filippini, Irene Tracey, Jonathan C.W. Brooks, Stephen M. Smith, Mark Jenkinson, Clare E. MacKay

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)


Background Functional magnetic resonance imaging (fMRI) has great potential for measuring mechanisms of functional changes in Alzheimer's disease (AD) and mild cognitive impairment, but task fMRI studies have produced conflicting results, partly due to failure to account for underlying morphological changes and to variations in patients' ability to perform the tasks. Resting fMRI has potential for assessing brain function independently from a task, but greater understanding of how networks of resting functional connectivity relate to the functioning of the brain is needed. We combined resting fMRI and task fMRI to examine the correspondence between these methods in individuals with cognitive impairment. Methods Eighty elderly (25 control subjects, 25 mild cognitive impairment, 30 AD) underwent a combined multimodal magnetic resonance imaging protocol including task fMRI and resting fMRI. Task fMRI data were acquired during the execution of a memory paradigm designed to account for differences in task performance. Structural and physiological confounds were modeled for both fMRI modalities. Results Successful recognition was associated with increased task fMRI activation in lateral prefrontal regions in AD relative to control subjects; this overlapped with increased resting fMRI functional connectivity in the same regions. Conclusions Our results show that task fMRI and resting fMRI are sensitive markers of residual ability over the known changes in brain morphology and cognition occurring in AD and suggest that resting fMRI has a potential to measure the effect of new treatments.

Original languageEnglish
Pages (from-to)375-383
Number of pages9
JournalBiological Psychiatry
Issue number5
Publication statusPublished - 1 Sep 2013


  • AD
  • functional connectivity
  • functional magnetic resonance imaging (fMRI)
  • MCI
  • MRI
  • resting fMRI
  • task fMRI

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