Reversal of inappropriate peripheral vascular responses in hypertrophic cardiomyopathy

Rajesh Thaman, Perry M Elliott, Jaymin S Shah, Bryan Mist, Lynne Williams, Ross T Murphy, William J McKenna, Michael P Frenneaux

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24 Citations (Scopus)


We assessed the frequency of abnormal forearm vasodilator responses during lower body negative pressure (LBNP) in 21 non-obstructive hypertrophic cardiomyopathy (HCM) patients (31 +/- 8 [20 to 43] years) with abnormal blood pressure response (ABPR) to exercise and the effects of three drugs used to treat vasovagal syncope (propranolol, clonidine, and paroxetine) in a double-blind crossover study.
Original languageEnglish
Pages (from-to)883-92
Number of pages10
JournalJournal of the American College of Cardiology
Issue number5
Publication statusPublished - 6 Sep 2005


  • Adrenergic beta-Antagonists
  • Adult
  • Blood Pressure
  • Cardiomyopathy, Hypertrophic, Familial
  • Clonidine
  • Cross-Over Studies
  • Double-Blind Method
  • Exercise Test
  • Female
  • Humans
  • Lower Extremity
  • Male
  • Paroxetine
  • Propranolol
  • Syncope, Vasovagal
  • Vasodilation

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