Reversal of inappropriate peripheral vascular responses in hypertrophic cardiomyopathy

Rajesh Thaman; Perry M Elliott; Jaymin S Shah; Bryan Mist; Lynne Williams; Ross T Murphy; William J McKenna; Michael P Frenneaux

doi:10.1016/j.jacc.2005.05.053

Reversal of inappropriate peripheral vascular responses in hypertrophic cardiomyopathy

Rajesh Thaman, Perry M Elliott, Jaymin S Shah, Bryan Mist, Lynne Williams, Ross T Murphy, William J McKenna, Michael P Frenneaux

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

We assessed the frequency of abnormal forearm vasodilator responses during lower body negative pressure (LBNP) in 21 non-obstructive hypertrophic cardiomyopathy (HCM) patients (31 +/- 8 [20 to 43] years) with abnormal blood pressure response (ABPR) to exercise and the effects of three drugs used to treat vasovagal syncope (propranolol, clonidine, and paroxetine) in a double-blind crossover study.

Original language	English
Pages (from-to)	883-92
Number of pages	10
Journal	Journal of the American College of Cardiology
Volume	46
Issue number	5
DOIs	https://doi.org/10.1016/j.jacc.2005.05.053
Publication status	Published - 6 Sept 2005

Keywords

Adrenergic beta-Antagonists
Adult
Blood Pressure
Cardiomyopathy, Hypertrophic, Familial
Clonidine
Cross-Over Studies
Double-Blind Method
Exercise Test
Female
Humans
Lower Extremity
Male
Paroxetine
Propranolol
Syncope, Vasovagal
Vasodilation

Access to Document

10.1016/j.jacc.2005.05.053

Cite this

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title = "Reversal of inappropriate peripheral vascular responses in hypertrophic cardiomyopathy",

abstract = "We assessed the frequency of abnormal forearm vasodilator responses during lower body negative pressure (LBNP) in 21 non-obstructive hypertrophic cardiomyopathy (HCM) patients (31 +/- 8 [20 to 43] years) with abnormal blood pressure response (ABPR) to exercise and the effects of three drugs used to treat vasovagal syncope (propranolol, clonidine, and paroxetine) in a double-blind crossover study.",

keywords = "Adrenergic beta-Antagonists, Adult, Blood Pressure, Cardiomyopathy, Hypertrophic, Familial, Clonidine, Cross-Over Studies, Double-Blind Method, Exercise Test, Female, Humans, Lower Extremity, Male, Paroxetine, Propranolol, Syncope, Vasovagal, Vasodilation",

author = "Rajesh Thaman and Elliott, {Perry M} and Shah, {Jaymin S} and Bryan Mist and Lynne Williams and Murphy, {Ross T} and McKenna, {William J} and Frenneaux, {Michael P}",

year = "2005",

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doi = "10.1016/j.jacc.2005.05.053",

language = "English",

volume = "46",

pages = "883--92",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

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TY - JOUR

T1 - Reversal of inappropriate peripheral vascular responses in hypertrophic cardiomyopathy

AU - Thaman, Rajesh

AU - Elliott, Perry M

AU - Shah, Jaymin S

AU - Mist, Bryan

AU - Williams, Lynne

AU - Murphy, Ross T

AU - McKenna, William J

AU - Frenneaux, Michael P

PY - 2005/9/6

Y1 - 2005/9/6

N2 - We assessed the frequency of abnormal forearm vasodilator responses during lower body negative pressure (LBNP) in 21 non-obstructive hypertrophic cardiomyopathy (HCM) patients (31 +/- 8 [20 to 43] years) with abnormal blood pressure response (ABPR) to exercise and the effects of three drugs used to treat vasovagal syncope (propranolol, clonidine, and paroxetine) in a double-blind crossover study.

AB - We assessed the frequency of abnormal forearm vasodilator responses during lower body negative pressure (LBNP) in 21 non-obstructive hypertrophic cardiomyopathy (HCM) patients (31 +/- 8 [20 to 43] years) with abnormal blood pressure response (ABPR) to exercise and the effects of three drugs used to treat vasovagal syncope (propranolol, clonidine, and paroxetine) in a double-blind crossover study.

KW - Adrenergic beta-Antagonists

KW - Adult

KW - Blood Pressure

KW - Cardiomyopathy, Hypertrophic, Familial

KW - Clonidine

KW - Cross-Over Studies

KW - Double-Blind Method

KW - Exercise Test

KW - Female

KW - Humans

KW - Lower Extremity

KW - Male

KW - Paroxetine

KW - Propranolol

KW - Syncope, Vasovagal

KW - Vasodilation

U2 - 10.1016/j.jacc.2005.05.053

DO - 10.1016/j.jacc.2005.05.053

M3 - Article

C2 - 16139140

SN - 0735-1097

VL - 46

SP - 883

EP - 892

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 5

ER -