Reversible DNA i-motif to hairpin switching induced by copper(II) cations

Henry Albert Day; Elisé Patricia Wright; Colin John MacDonald; Andrew James Gates; Zoë Ann Ella Waller

doi:10.1039/c5cc05111h

Reversible DNA i-motif to hairpin switching induced by copper(II) cations

Henry Albert Day, Elisé Patricia Wright, Colin John MacDonald, Andrew James Gates, Zoë Ann Ella Waller

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

14 Downloads (Pure)

Abstract

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.

Original language	English
Pages (from-to)	14099-14102
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	74
Early online date	3 Aug 2015
DOIs	https://doi.org/10.1039/c5cc05111h
Publication status	Published - 7 Aug 2015

Access to Document

10.1039/c5cc05111hLicence: CC BY

Day_etal_ChemComm_2015Final published version, 2.07 MB

Andrew Gates
- A.Gatesuea.acuk
- School of Biological Sciences - Associate Professor in Bacterial Bioenergetics
- Centre for Molecular and Structural Biochemistry - Member
- Molecular Microbiology - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching & Research

Investigating the stability and function of i-motif DNA.
Waller, Z.
Biotechnology and Biological Sciences Research Council
30/11/14 → 29/12/17
Project: Research

Cite this

@article{04ca8d96b22f4c66b916a5f132430cfd,

title = "Reversible DNA i-motif to hairpin switching induced by copper(II) cations",

abstract = "i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.",

author = "Day, {Henry Albert} and Wright, {Elis{\'e} Patricia} and MacDonald, {Colin John} and Gates, {Andrew James} and Waller, {Zo{\"e} Ann Ella}",

note = "This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. ",

year = "2015",

month = aug,

day = "7",

doi = "10.1039/c5cc05111h",

language = "English",

volume = "51",

pages = "14099--14102",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "74",

}

TY - JOUR

T1 - Reversible DNA i-motif to hairpin switching induced by copper(II) cations

AU - Day, Henry Albert

AU - Wright, Elisé Patricia

AU - MacDonald, Colin John

AU - Gates, Andrew James

AU - Waller, Zoë Ann Ella

N1 - This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

PY - 2015/8/7

Y1 - 2015/8/7

N2 - i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.

AB - i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.

U2 - 10.1039/c5cc05111h

DO - 10.1039/c5cc05111h

M3 - Article

C2 - 26252811

VL - 51

SP - 14099

EP - 14102

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 74

ER -

Reversible DNA i-motif to hairpin switching induced by copper(II) cations

Abstract

Access to Document

Profiles

Andrew Gates

Projects

Investigating the stability and function of i-motif DNA.

Cite this