Reversible DNA i-motif to hairpin switching induced by copper(II) cations

Henry Albert Day, Elisé Patricia Wright, Colin John MacDonald, Andrew James Gates, Zoë Ann Ella Waller

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i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(ii) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.
Original languageEnglish
Pages (from-to)14099-14102
Number of pages4
JournalChemical Communications
Issue number74
Early online date3 Aug 2015
Publication statusPublished - 7 Aug 2015

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