Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation

Carl Redshaw, Scott Watkins, Simon M. Humphrey, Philip C. Bulman Page, Shane Ashby, Yimin Chao, Christopher J. Herbert, Anja Mueller

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Rhenium(I) tricarbonyl complexes bearing a 2,4,7,9-tetraphenylphenanthroline ligand, where the 2,9-phenyl groups have either meta- or para-CF3 groups, have been screened against a selection of cell lines. The meta derivative shows anticancer activity against HeLa and A549 cell lines, whereas the para derivative causes proliferation of HL-60 cells, whilst showing toxicity towards A549 cells.
Original languageEnglish
Pages (from-to)23963-23966
Number of pages4
JournalRSC Advances
Volume3
Issue number46
DOIs
Publication statusPublished - 4 Oct 2013

Cite this