Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation

Carl Redshaw; Scott Watkins; Simon M. Humphrey; Philip C. Bulman Page; Shane Ashby; Yimin Chao; Christopher J. Herbert; Anja Mueller

doi:10.1039/c3ra43207f

Rhenium(I) phenanthrolines bearing electron withdrawing CF₃ substituents: synthesis, characterization and biological evaluation

Carl Redshaw, Scott Watkins, Simon M. Humphrey, Philip C. Bulman Page, Shane Ashby, Yimin Chao, Christopher J. Herbert, Anja Mueller

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Rhenium(I) tricarbonyl complexes bearing a 2,4,7,9-tetraphenylphenanthroline ligand, where the 2,9-phenyl groups have either meta- or para-CF3 groups, have been screened against a selection of cell lines. The meta derivative shows anticancer activity against HeLa and A549 cell lines, whereas the para derivative causes proliferation of HL-60 cells, whilst showing toxicity towards A549 cells.

Original language	English
Pages (from-to)	23963-23966
Number of pages	4
Journal	RSC Advances
Volume	3
Issue number	46
DOIs	https://doi.org/10.1039/c3ra43207f
Publication status	Published - 4 Oct 2013

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10.1039/c3ra43207f

Cite this

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title = "Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation",

abstract = "Rhenium(I) tricarbonyl complexes bearing a 2,4,7,9-tetraphenylphenanthroline ligand, where the 2,9-phenyl groups have either meta- or para-CF3 groups, have been screened against a selection of cell lines. The meta derivative shows anticancer activity against HeLa and A549 cell lines, whereas the para derivative causes proliferation of HL-60 cells, whilst showing toxicity towards A549 cells.",

author = "Carl Redshaw and Scott Watkins and Humphrey, {Simon M.} and {Bulman Page}, {Philip C.} and Shane Ashby and Yimin Chao and Herbert, {Christopher J.} and Anja Mueller",

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AU - Redshaw, Carl

AU - Watkins, Scott

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AU - Bulman Page, Philip C.

AU - Ashby, Shane

AU - Chao, Yimin

AU - Herbert, Christopher J.

AU - Mueller, Anja

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AB - Rhenium(I) tricarbonyl complexes bearing a 2,4,7,9-tetraphenylphenanthroline ligand, where the 2,9-phenyl groups have either meta- or para-CF3 groups, have been screened against a selection of cell lines. The meta derivative shows anticancer activity against HeLa and A549 cell lines, whereas the para derivative causes proliferation of HL-60 cells, whilst showing toxicity towards A549 cells.

U2 - 10.1039/c3ra43207f

DO - 10.1039/c3ra43207f

M3 - Article

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EP - 23966

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