Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Anne Barton; Wendy Thomson; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Darren Plant; Laura J. Gibbons; Wellcome Trust Case Control Consortium; YEAR Consortium; BIRAC Consortium; Anthony G. Wilson; Deborah E. Bax; Ann W. Morgan; Paul Emery; Sophia Steer; Lynne Hocking; David M. Reid; Paul Wordsworth; Pille Harrison; Jane Worthington

doi:10.1038/ng.218

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Anne Barton, Wendy Thomson, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Darren Plant, Laura J. Gibbons, Wellcome Trust Case Control Consortium, YEAR Consortium, BIRAC Consortium, Anthony G. Wilson, Deborah E. Bax, Ann W. Morgan, Paul Emery, Sophia Steer, Lynne Hocking, David M. Reid, Paul Wordsworth, Pille HarrisonJane Worthington

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

133 Citations (Scopus)

Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Original language	English
Pages (from-to)	1156-1159
Number of pages	4
Journal	Nature Genetics
Volume	40
Issue number	10
DOIs	https://doi.org/10.1038/ng.218
Publication status	Published - Oct 2008

Keywords

Arthritis, Rheumatoid/genetics
Case-Control Studies
Chromosome Mapping
Chromosomes, Human, Pair 10/genetics
Chromosomes, Human, Pair 12/genetics
Chromosomes, Human, Pair 22/genetics
Genetic Linkage
Genetic Predisposition to Disease/genetics
Humans
Polymorphism, Single Nucleotide/genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.218

Cite this

Barton, A., Thomson, W., Ke, X., Eyre, S., Hinks, A., Bowes, J., Plant, D., Gibbons, L. J., Wellcome Trust Case Control Consortium, YEAR Consortium, BIRAC Consortium, Wilson, A. G., Bax, D. E., Morgan, A. W., Emery, P., Steer, S., Hocking, L., Reid, D. M., Wordsworth, P., ... Worthington, J. (2008). Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics, 40(10), 1156-1159. https://doi.org/10.1038/ng.218

Barton, Anne ; Thomson, Wendy ; Ke, Xiayi ; Eyre, Steve ; Hinks, Anne ; Bowes, John ; Plant, Darren ; Gibbons, Laura J. ; Wellcome Trust Case Control Consortium ; YEAR Consortium ; BIRAC Consortium ; Wilson, Anthony G. ; Bax, Deborah E. ; Morgan, Ann W. ; Emery, Paul ; Steer, Sophia ; Hocking, Lynne ; Reid, David M. ; Wordsworth, Paul ; Harrison, Pille ; Worthington, Jane. / Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. In: Nature Genetics. 2008 ; Vol. 40, No. 10. pp. 1156-1159.

@article{cb4d8b920a144c24b8c772d5ca1772ac,

title = "Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13",

abstract = "The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.",

keywords = "Arthritis, Rheumatoid/genetics, Case-Control Studies, Chromosome Mapping, Chromosomes, Human, Pair 10/genetics, Chromosomes, Human, Pair 12/genetics, Chromosomes, Human, Pair 22/genetics, Genetic Linkage, Genetic Predisposition to Disease/genetics, Humans, Polymorphism, Single Nucleotide/genetics",

author = "Anne Barton and Wendy Thomson and Xiayi Ke and Steve Eyre and Anne Hinks and John Bowes and Darren Plant and Gibbons, {Laura J.} and {Wellcome Trust Case Control Consortium} and {YEAR Consortium} and {BIRAC Consortium} and Wilson, {Anthony G.} and Bax, {Deborah E.} and Morgan, {Ann W.} and Paul Emery and Sophia Steer and Lynne Hocking and Reid, {David M.} and Paul Wordsworth and Pille Harrison and Jane Worthington and Karl Gaffney",

year = "2008",

month = oct,

doi = "10.1038/ng.218",

language = "English",

volume = "40",

pages = "1156--1159",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "10",

}

Barton, A, Thomson, W, Ke, X, Eyre, S, Hinks, A, Bowes, J, Plant, D, Gibbons, LJ, Wellcome Trust Case Control Consortium, YEAR Consortium, BIRAC Consortium, Wilson, AG, Bax, DE, Morgan, AW, Emery, P, Steer, S, Hocking, L, Reid, DM, Wordsworth, P, Harrison, P & Worthington, J 2008, 'Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13', Nature Genetics, vol. 40, no. 10, pp. 1156-1159. https://doi.org/10.1038/ng.218

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. / Barton, Anne; Thomson, Wendy; Ke, Xiayi; Eyre, Steve; Hinks, Anne; Bowes, John; Plant, Darren; Gibbons, Laura J.; Wellcome Trust Case Control Consortium; YEAR Consortium; BIRAC Consortium; Wilson, Anthony G.; Bax, Deborah E.; Morgan, Ann W.; Emery, Paul; Steer, Sophia; Hocking, Lynne; Reid, David M.; Wordsworth, Paul; Harrison, Pille; Worthington, Jane.

In: Nature Genetics, Vol. 40, No. 10, 10.2008, p. 1156-1159.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

AU - Barton, Anne

AU - Thomson, Wendy

AU - Ke, Xiayi

AU - Eyre, Steve

AU - Hinks, Anne

AU - Bowes, John

AU - Plant, Darren

AU - Gibbons, Laura J.

AU - Wellcome Trust Case Control Consortium

AU - YEAR Consortium

AU - BIRAC Consortium

AU - Wilson, Anthony G.

AU - Bax, Deborah E.

AU - Morgan, Ann W.

AU - Emery, Paul

AU - Steer, Sophia

AU - Hocking, Lynne

AU - Reid, David M.

AU - Wordsworth, Paul

AU - Harrison, Pille

AU - Worthington, Jane

AU - Gaffney, Karl

PY - 2008/10

Y1 - 2008/10

N2 - The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

AB - The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

KW - Arthritis, Rheumatoid/genetics

KW - Case-Control Studies

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 10/genetics

KW - Chromosomes, Human, Pair 12/genetics

KW - Chromosomes, Human, Pair 22/genetics

KW - Genetic Linkage

KW - Genetic Predisposition to Disease/genetics

KW - Humans

KW - Polymorphism, Single Nucleotide/genetics

U2 - 10.1038/ng.218

DO - 10.1038/ng.218

M3 - Article

C2 - 18794857

VL - 40

SP - 1156

EP - 1159

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -