Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Anne Barton, Wendy Thomson, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Darren Plant, Laura J. Gibbons, Wellcome Trust Case Control Consortium, YEAR Consortium, BIRAC Consortium, Anthony G. Wilson, Deborah E. Bax, Ann W. Morgan, Paul Emery, Sophia Steer, Lynne Hocking, David M. Reid, Paul Wordsworth, Pille HarrisonJane Worthington

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Original languageEnglish
Pages (from-to)1156-1159
Number of pages4
JournalNature Genetics
Volume40
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Arthritis, Rheumatoid/genetics
  • Case-Control Studies
  • Chromosome Mapping
  • Chromosomes, Human, Pair 10/genetics
  • Chromosomes, Human, Pair 12/genetics
  • Chromosomes, Human, Pair 22/genetics
  • Genetic Linkage
  • Genetic Predisposition to Disease/genetics
  • Humans
  • Polymorphism, Single Nucleotide/genetics

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