Risk of breast cancer after onset of type 2 diabetes: Evidence of detection bias in postmenopausal women

Samantha L. Bowker; Kathryn Richardson; Carlo A. Marra; Jeffrey A. Johnson

doi:10.2337/dc11-1199

Risk of breast cancer after onset of type 2 diabetes: Evidence of detection bias in postmenopausal women

Samantha L. Bowker, Kathryn Richardson, Carlo A. Marra, Jeffrey A. Johnson

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

OBJECTIVE: To examine the risk of breast cancer in pre- and postmenopausal women with type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS: This was a population-based retrospective cohort study. Cox regression, stratified by pre- (<55 years) and postmenopausal (≥55 years) status, was used to estimate hazard ratios (HRs) for breast cancer, during earlier (0–3 months) and later (3 months to 10 years) time windows after diabetes index date.

RESULTS: Compared with women without T2D, HRs for breast cancer were 0.95 (95% CI 0.48–1.86; P = 0.88) and 1.31 (0.92–1.86; P = 0.14) in pre- and postmenopausal women with T2D, respectively, in the early time window, and 0.92 (0.75–1.13; P = 0.45) and 1.00 (0.90–1.11; P = 0.93) in pre- and postmenopausal women with T2D, respectively, in the later time window.

CONCLUSIONS: We observed a trend toward an increased risk of breast cancer in postmenopausal women with T2D, but only in the time period immediately after diabetes index date.

Original language	English
Pages (from-to)	2542-2544
Number of pages	3
Journal	Diabetes Care
Volume	34
Issue number	12
DOIs	https://doi.org/10.2337/dc11-1199
Publication status	Published - 2011

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10.2337/dc11-1199Licence: CC BY-NC-ND

Cite this

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title = "Risk of breast cancer after onset of type 2 diabetes: Evidence of detection bias in postmenopausal women",

abstract = "OBJECTIVE: To examine the risk of breast cancer in pre- and postmenopausal women with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: This was a population-based retrospective cohort study. Cox regression, stratified by pre- (<55 years) and postmenopausal (≥55 years) status, was used to estimate hazard ratios (HRs) for breast cancer, during earlier (0–3 months) and later (3 months to 10 years) time windows after diabetes index date. RESULTS: Compared with women without T2D, HRs for breast cancer were 0.95 (95% CI 0.48–1.86; P = 0.88) and 1.31 (0.92–1.86; P = 0.14) in pre- and postmenopausal women with T2D, respectively, in the early time window, and 0.92 (0.75–1.13; P = 0.45) and 1.00 (0.90–1.11; P = 0.93) in pre- and postmenopausal women with T2D, respectively, in the later time window. CONCLUSIONS: We observed a trend toward an increased risk of breast cancer in postmenopausal women with T2D, but only in the time period immediately after diabetes index date.",

author = "Bowker, {Samantha L.} and Kathryn Richardson and Marra, {Carlo A.} and Johnson, {Jeffrey A.}",

year = "2011",

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T1 - Risk of breast cancer after onset of type 2 diabetes: Evidence of detection bias in postmenopausal women

AU - Bowker, Samantha L.

AU - Richardson, Kathryn

AU - Marra, Carlo A.

AU - Johnson, Jeffrey A.

PY - 2011

Y1 - 2011

N2 - OBJECTIVE: To examine the risk of breast cancer in pre- and postmenopausal women with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: This was a population-based retrospective cohort study. Cox regression, stratified by pre- (<55 years) and postmenopausal (≥55 years) status, was used to estimate hazard ratios (HRs) for breast cancer, during earlier (0–3 months) and later (3 months to 10 years) time windows after diabetes index date. RESULTS: Compared with women without T2D, HRs for breast cancer were 0.95 (95% CI 0.48–1.86; P = 0.88) and 1.31 (0.92–1.86; P = 0.14) in pre- and postmenopausal women with T2D, respectively, in the early time window, and 0.92 (0.75–1.13; P = 0.45) and 1.00 (0.90–1.11; P = 0.93) in pre- and postmenopausal women with T2D, respectively, in the later time window. CONCLUSIONS: We observed a trend toward an increased risk of breast cancer in postmenopausal women with T2D, but only in the time period immediately after diabetes index date.

AB - OBJECTIVE: To examine the risk of breast cancer in pre- and postmenopausal women with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: This was a population-based retrospective cohort study. Cox regression, stratified by pre- (<55 years) and postmenopausal (≥55 years) status, was used to estimate hazard ratios (HRs) for breast cancer, during earlier (0–3 months) and later (3 months to 10 years) time windows after diabetes index date. RESULTS: Compared with women without T2D, HRs for breast cancer were 0.95 (95% CI 0.48–1.86; P = 0.88) and 1.31 (0.92–1.86; P = 0.14) in pre- and postmenopausal women with T2D, respectively, in the early time window, and 0.92 (0.75–1.13; P = 0.45) and 1.00 (0.90–1.11; P = 0.93) in pre- and postmenopausal women with T2D, respectively, in the later time window. CONCLUSIONS: We observed a trend toward an increased risk of breast cancer in postmenopausal women with T2D, but only in the time period immediately after diabetes index date.

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DO - 10.2337/dc11-1199

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JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

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