Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis

Chun Shing Kwok, Aaron Kobina Arthur, Chukwudubem Ifeanyichukwu Anibueze, Sonal Singh, Rodrigo Cavallazzi, Yoon Kong Loke

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468 Citations (Scopus)


Several studies have raised concern regarding the possible association between proton-pump inhibitors (PPIs) and Clostridium difficile infection (CDI). We aimed to perform a systematic review of incident and recurrent CDI in PPI users, and to evaluate the relative impact of concurrent antibiotic use, or switching acid suppression to histamine-2-receptor antagonists (H2RAs).
Original languageEnglish
Pages (from-to)1011-9
Number of pages9
JournalThe American Journal of Gastroenterology
Issue number7
Publication statusPublished - Jul 2012


  • Anti-Bacterial Agents
  • Clostridium difficile
  • Enterocolitis, Pseudomembranous
  • Histamine H2 Antagonists
  • Humans
  • Incidence
  • Proton Pump Inhibitors
  • Recurrence
  • Risk Factors

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