Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis

Chun Shing Kwok; Aaron Kobina Arthur; Chukwudubem Ifeanyichukwu Anibueze; Sonal Singh; Rodrigo Cavallazzi; Yoon Kong Loke

doi:10.1038/ajg.2012.108

Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis

Chun Shing Kwok, Aaron Kobina Arthur, Chukwudubem Ifeanyichukwu Anibueze, Sonal Singh, Rodrigo Cavallazzi, Yoon Kong Loke

Research output: Contribution to journal › Article › peer-review

473 Citations (Scopus)

Abstract

Several studies have raised concern regarding the possible association between proton-pump inhibitors (PPIs) and Clostridium difficile infection (CDI). We aimed to perform a systematic review of incident and recurrent CDI in PPI users, and to evaluate the relative impact of concurrent antibiotic use, or switching acid suppression to histamine-2-receptor antagonists (H2RAs).

Original language	English
Pages (from-to)	1011-9
Number of pages	9
Journal	The American Journal of Gastroenterology
Volume	107
Issue number	7
DOIs	https://doi.org/10.1038/ajg.2012.108
Publication status	Published - Jul 2012

Keywords

Anti-Bacterial Agents
Clostridium difficile
Enterocolitis, Pseudomembranous
Histamine H2 Antagonists
Humans
Incidence
Proton Pump Inhibitors
Recurrence
Risk Factors

Access to Document

10.1038/ajg.2012.108

Cite this

@article{349e2f7f9b5a4169a32dbaa166ba0823,

title = "Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis",

abstract = "Several studies have raised concern regarding the possible association between proton-pump inhibitors (PPIs) and Clostridium difficile infection (CDI). We aimed to perform a systematic review of incident and recurrent CDI in PPI users, and to evaluate the relative impact of concurrent antibiotic use, or switching acid suppression to histamine-2-receptor antagonists (H2RAs).",

keywords = "Anti-Bacterial Agents, Clostridium difficile, Enterocolitis, Pseudomembranous, Histamine H2 Antagonists, Humans, Incidence, Proton Pump Inhibitors, Recurrence, Risk Factors",

author = "Kwok, {Chun Shing} and Arthur, {Aaron Kobina} and Anibueze, {Chukwudubem Ifeanyichukwu} and Sonal Singh and Rodrigo Cavallazzi and Loke, {Yoon Kong}",

year = "2012",

month = jul,

doi = "10.1038/ajg.2012.108",

language = "English",

volume = "107",

pages = "1011--9",

journal = "American Journal of Gastroenterology",

issn = "0002-9270",

publisher = "Nature Publishing Group",

number = "7",

}

Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics : meta-analysis. / Kwok, Chun Shing; Arthur, Aaron Kobina; Anibueze, Chukwudubem Ifeanyichukwu; Singh, Sonal; Cavallazzi, Rodrigo; Loke, Yoon Kong.

In: The American Journal of Gastroenterology, Vol. 107, No. 7, 07.2012, p. 1011-9.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics

T2 - meta-analysis

AU - Kwok, Chun Shing

AU - Arthur, Aaron Kobina

AU - Anibueze, Chukwudubem Ifeanyichukwu

AU - Singh, Sonal

AU - Cavallazzi, Rodrigo

AU - Loke, Yoon Kong

PY - 2012/7

Y1 - 2012/7

N2 - Several studies have raised concern regarding the possible association between proton-pump inhibitors (PPIs) and Clostridium difficile infection (CDI). We aimed to perform a systematic review of incident and recurrent CDI in PPI users, and to evaluate the relative impact of concurrent antibiotic use, or switching acid suppression to histamine-2-receptor antagonists (H2RAs).

AB - Several studies have raised concern regarding the possible association between proton-pump inhibitors (PPIs) and Clostridium difficile infection (CDI). We aimed to perform a systematic review of incident and recurrent CDI in PPI users, and to evaluate the relative impact of concurrent antibiotic use, or switching acid suppression to histamine-2-receptor antagonists (H2RAs).

KW - Anti-Bacterial Agents

KW - Clostridium difficile

KW - Enterocolitis, Pseudomembranous

KW - Histamine H2 Antagonists

KW - Humans

KW - Incidence

KW - Proton Pump Inhibitors

KW - Recurrence

KW - Risk Factors

U2 - 10.1038/ajg.2012.108

DO - 10.1038/ajg.2012.108

M3 - Article

C2 - 22525304

VL - 107

SP - 1011

EP - 1019

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 7

ER -