Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis

Chun Shing Kwok; Aaron Kobina Arthur; Chukwudubem Ifeanyichukwu Anibueze; Sonal Singh; Rodrigo Cavallazzi; Yoon Kong Loke

doi:10.1038/ajg.2012.108

Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis

Chun Shing Kwok, Aaron Kobina Arthur, Chukwudubem Ifeanyichukwu Anibueze, Sonal Singh, Rodrigo Cavallazzi, Yoon Kong Loke

Research output: Contribution to journal › Article › peer-review

504 Citations (Scopus)

Abstract

Several studies have raised concern regarding the possible association between proton-pump inhibitors (PPIs) and Clostridium difficile infection (CDI). We aimed to perform a systematic review of incident and recurrent CDI in PPI users, and to evaluate the relative impact of concurrent antibiotic use, or switching acid suppression to histamine-2-receptor antagonists (H2RAs).

Original language	English
Pages (from-to)	1011-9
Number of pages	9
Journal	The American Journal of Gastroenterology
Volume	107
Issue number	7
DOIs	https://doi.org/10.1038/ajg.2012.108
Publication status	Published - Jul 2012

Keywords

Anti-Bacterial Agents
Clostridium difficile
Enterocolitis, Pseudomembranous
Histamine H2 Antagonists
Humans
Incidence
Proton Pump Inhibitors
Recurrence
Risk Factors

Access to Document

10.1038/ajg.2012.108

Cite this

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title = "Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis",

abstract = "Several studies have raised concern regarding the possible association between proton-pump inhibitors (PPIs) and Clostridium difficile infection (CDI). We aimed to perform a systematic review of incident and recurrent CDI in PPI users, and to evaluate the relative impact of concurrent antibiotic use, or switching acid suppression to histamine-2-receptor antagonists (H2RAs).",

keywords = "Anti-Bacterial Agents, Clostridium difficile, Enterocolitis, Pseudomembranous, Histamine H2 Antagonists, Humans, Incidence, Proton Pump Inhibitors, Recurrence, Risk Factors",

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AU - Cavallazzi, Rodrigo

AU - Loke, Yoon Kong

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KW - Enterocolitis, Pseudomembranous

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