Risk of sudden cardiac death: Are coronary chronic total occlusions an additional risk factor?

Ioannis Merinopoulos, Natasha Corballis, Simon C Eccleshall, Vassilios S Vassiliou

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Sudden arrhythmic cardiac death remains a significant, potentially reversible, cardiological challenge in terms of creating accurate risk prediction models. The current guidelines for implantable cardioverter defibrillator (ICD) therapy are mainly based on left ventricular ejection fraction despite its low sensitivity and specificity in predicting sudden cardiac death (SCD). Chronic total occlusions have been associated with increased mortality but further research is required to clarify if they should be incorporated in a risk model predicting SCD aiming to identify patients that would benefit from ICD therapy even with preserved ejection fraction.

Original languageEnglish
Pages (from-to)250-253
Number of pages4
JournalWorld Journal of Cardiology
Issue number12
Publication statusPublished - 26 Dec 2018


  • Sudden cardiac death
  • Chronic total occlusion
  • Left ventricular ejection fraction
  • Implantable cardioverter defibrillator

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