RNA polymerase IV directs silencing of endogenous DNA

A. J. Herr, M. B. Jensen, T. Dalmay, D. C. Baulcombe

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586 Citations (Scopus)


Plants encode subunits for a fourth RNA polymerase (Pol IV) in addition to the well-known DNA-dependent RNA polymerases I, II, and III. By mutation of the two largest subunits (NRPD1a and NRPD2), we show that Pol IV silences certain transposons and repetitive DNA in a short interfering RNA pathway involving RNA-dependent RNA polymerase 2 and Dicer-like 3. The existence of this distinct silencing polymerase may explain the paradoxical involvement of an RNA silencing pathway in maintenance of transcriptional silencing.
Original languageEnglish
Pages (from-to)118-120
Number of pages3
Issue number5718
Publication statusPublished - 2005

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