Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

Sayqa Arif; Alessandra Borgognone; Erica Lai-Sze Lin; Aine O'Sullivan; Vishal Sharma; Nigel Drury; Ashvini Menon; Peter Nightingale; Jorge Mascaro; Robert S Bonser; John Horowitz; Martin Feelisch; Michael Frenneaux; Melanie Madhani

doi:10.1111/bph.13122

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

Sayqa Arif, Alessandra Borgognone, Erica Lai-Sze Lin, Aine O'Sullivan, Vishal Sharma, Nigel Drury, Ashvini Menon, Peter Nightingale, Jorge Mascaro, Robert S Bonser, John Horowitz, Martin Feelisch, Michael Frenneaux, Melanie Madhani

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

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Abstract

Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined. In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation under normoxia and hypoxia in the rat and human vasculature.

Original language	English
Pages (from-to)	3341-3352
Number of pages	12
Journal	British Journal of Pharmacology
Volume	172
Issue number	13
Early online date	29 Apr 2015
DOIs	https://doi.org/10.1111/bph.13122
Publication status	Published - Jul 2015

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Cite this

Arif, S., Borgognone, A., Lin, E. L-S., O'Sullivan, A., Sharma, V., Drury, N., Menon, A., Nightingale, P., Mascaro, J., Bonser, R. S., Horowitz, J., Feelisch, M., Frenneaux, M., & Madhani, M. (2015). Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans. British Journal of Pharmacology, 172(13), 3341-3352. https://doi.org/10.1111/bph.13122

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abstract = "Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined. In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation under normoxia and hypoxia in the rat and human vasculature.",

author = "Sayqa Arif and Alessandra Borgognone and Lin, {Erica Lai-Sze} and Aine O'Sullivan and Vishal Sharma and Nigel Drury and Ashvini Menon and Peter Nightingale and Jorge Mascaro and Bonser, {Robert S} and John Horowitz and Martin Feelisch and Michael Frenneaux and Melanie Madhani",

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Arif, S, Borgognone, A, Lin, EL-S, O'Sullivan, A, Sharma, V, Drury, N, Menon, A, Nightingale, P, Mascaro, J, Bonser, RS, Horowitz, J, Feelisch, M, Frenneaux, M & Madhani, M 2015, 'Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans', British Journal of Pharmacology, vol. 172, no. 13, pp. 3341-3352. https://doi.org/10.1111/bph.13122

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T1 - Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

AU - Arif, Sayqa

AU - Borgognone, Alessandra

AU - Lin, Erica Lai-Sze

AU - O'Sullivan, Aine

AU - Sharma, Vishal

AU - Drury, Nigel

AU - Menon, Ashvini

AU - Nightingale, Peter

AU - Mascaro, Jorge

AU - Bonser, Robert S

AU - Horowitz, John

AU - Feelisch, Martin

AU - Frenneaux, Michael

AU - Madhani, Melanie

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AB - Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined. In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation under normoxia and hypoxia in the rat and human vasculature.

U2 - 10.1111/bph.13122

DO - 10.1111/bph.13122

M3 - Article

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VL - 172

SP - 3341

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JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

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