Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

Sayqa Arif, Alessandra Borgognone, Erica Lai-Sze Lin, Aine O'Sullivan, Vishal Sharma, Nigel Drury, Ashvini Menon, Peter Nightingale, Jorge Mascaro, Robert S Bonser, John Horowitz, Martin Feelisch, Michael Frenneaux, Melanie Madhani

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Abstract

Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined. In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation under normoxia and hypoxia in the rat and human vasculature.
Original languageEnglish
Pages (from-to)3341-3352
Number of pages12
JournalBritish Journal of Pharmacology
Volume172
Issue number13
Early online date29 Apr 2015
DOIs
Publication statusPublished - Jul 2015

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