Role of cardiac T1 mapping and extracellular volume (ECV) in the assessment of myocardial infarction

Pankaj Garg, Laura C. Saunders, Andrew J. Swift, Jim W. Wild, Sven Plein

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)
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Although late gadolinium enhancement on cardiac magnetic resonance imaging remains the reference standard for scar assessment, it does not provide quantitative information about the extent of pathophysiological changes within the scar tissue. T1 mapping and extracellular volume (ECV) mapping are steadily becoming diagnostic and prognostically useful tests for in vivo myocardial histology, influencing clinical decision making. Quantitative native T1 maps (acquired without a contrast agent) represent the longitudinal relaxation time within the myocardium and changes with myocardial extracellular water (edema, focal, or diffuse fibrosis), fat, iron, and amyloid protein content. Post-contrast ECV maps estimate the size of the extracellular space and have sensitivity in the identification of interstitial disease. Both pre- and post-contrast T1 map ping are emerging as comprehensive tools for the assessment of numerous conditions including ischemic scarring that occurs post myocardial infarction (MI). This review outlines the current evidence and potential future role of T1 mapping in MI. We conclude by highlighting some of the remaining challenges such as quality control, standardization of image acquisition for clinical practice, and automated methods for quantifying infarct size, area at risk, and myocardial salvage post MI.
Original languageEnglish
Pages (from-to)404-411
Number of pages8
JournalAnatolian Journal of Cardiology
Publication statusPublished - 1 Jun 2018

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