Role of natriuretic peptides in regulation of conduit artery distensibility

Matthias Schmitt, Ahmad Qasem, Carmel McEniery, Ian B Wilkinson, Vicki Tatarinoff, Kate Noble, John Klemes, Nicola Payne, Michael P Frenneaux, John Cockcroft, Albert Avolio

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28 Citations (Scopus)

Abstract

Arterial distensibility, assessed by the pulse-wave velocity (PWV), is an independent predictor of cardiovascular risk. We investigated whether natriuretic peptides, acting locally, modify conduit artery distensibility in vivo. All studies were conducted in anesthetized sheep (n = 18) by using a validated ovine hindlimb model. In brief, the PWV was calculated, with the use of the foot-to-foot methodology, from two pressure waveforms recorded simultaneously with a high-fidelity dual pressure-sensing catheter placed in the common iliac artery. Drugs were infused either proximally, via the catheter to perfuse the segment of artery under study, or distally, via the sheath to control for any reflex changes in flow or sympathetic activation. First, the effects of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP) were studied. Second, the role of endogenous ANP was investigated by infusing the natriuretic peptide receptor type A (NPRA)-selective receptor antagonist A71915. Third, A71915 was coinfused with ANP. Fourth, the NPRC-selective agonist cANF was infused. Infusion of CNP or des-[Gln18Ser19Gly20Leu21Gly22]-ANF-(4-23)-NH2 (cANF) had no effect on iliac PWV. However, infusion of ANP, and to a lesser degree BNP, resulted in a reduction in PWV (-9%; P
Original languageEnglish
Pages (from-to)H1167-71
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume287
Issue number3
DOIs
Publication statusPublished - Sep 2004

Keywords

  • Animals
  • Atrial Natriuretic Factor
  • Dose-Response Relationship, Drug
  • Drug Combinations
  • Humans
  • Iliac Artery
  • Infusions, Intra-Arterial
  • Natriuretic Peptide, Brain
  • Natriuretic Peptide, C-Type
  • Natriuretic Peptides
  • Peptide Fragments
  • Pulse
  • Sheep
  • Tetrahydroisoquinolines
  • Time Factors
  • Vasodilation

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