Role of NF-κB pathway in the transition of mouse secondary follicles to antral follicles

Jun Jie Xu, Guang Wang, Xin Luo, Li-Jing Wang, Yongping Bao, Xuesong Yang

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NF-kappaB (NF-κB) signaling is involved in regulating a great number of normal and abnormal cellular events. However, little is known about its role in ovarian follicular development. In this study, we found NF-κB signaling is activated during the transition from secondary to antral follicles. We generated active NF-κB mice and found that antral follicular numbers were higher than wild-types ovaries. Activation of NF-κB signaling could enhance granulosa cell proliferation and regress granulosa cell apoptosis of mouse ovarian follicles. Higher FSHR and LHCGR expressions were observed in active NF-κB ovaries compared to wild-type. Furthermore, we confirmed that NF-κB signaling was indeed involved in the granulosa cell viability and proliferation through FSHR using COV434 cell line. This is the first experimental evidence that NF-κB signaling is implicated in the control of follicular development through FSHR and its corresponding target molecules, which might be achieved by targeting proliferation and apoptosis in follicular granulosa cells.
Original languageEnglish
Pages (from-to)22565-22580
Number of pages16
JournalJournal of Cellular Physiology
Issue number12
Early online date17 May 2019
Publication statusPublished - Dec 2019

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